From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1987
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.20
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cckar) endoplasmic reticulum (Cckar) plasma membrane (Cckar)
lysosome (Cckar) cytoplasm (Cckar) signal transducer activity (Cckar)
Anatomy Link Frequency
portal vein 1
Cckar (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 4 100.00 Very High Very High Very High
substance P 2 99.36 Very High Very High Very High
antagonist 1 99.20 Very High Very High Very High
lidocaine 2 95.44 Very High Very High Very High
qutenza 1 83.28 Quite High
tetrodotoxin 1 75.84 Quite High
Pain 3 75.00 Quite High
withdrawal 2 44.16 Quite Low
Thermal hyperalgesia 2 37.52 Quite Low
Hippocampus 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 3 75.00 Quite High
Targeted Disruption 1 75.00 Quite High
Hyperalgesia 2 37.52 Quite Low
Urological Neuroanatomy 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Otsuka Long-Evans Tokushima Fatty (OLETF) rats lack cholecystokinin-A receptor (CCK-AR) because of a genetic abnormality.
Neg (lack) Gene_expression (lack) of CCK-AR associated with cholecystokinin
1) Confidence 0.65 Published 2006 Journal J. Pharmacol. Sci. Section Abstract Doc Link 16891771 Disease Relevance 0.20 Pain Relevance 0.21
Some animals were pretreated with indomethacin (5 mg/kg, ip), L-NAME (9, 18, 36 and 72 micromol/kg, iv), atropine sulfate (1-2 mg/kg, iv), CCK-1 and CCK-2 receptor antagonists (L-364,718 and L-365,260, 1 mg/kg, iv), exendin (9-39) amide (35 nmol/kg, iv) and lidocaine (74 micromol/kg, iv) prior to the infusion of GLP-2 (4.6 nmol/kg).
Gene_expression (pretreated) of CCK-1 associated with antagonist and lidocaine
2) Confidence 0.18 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17346812 Disease Relevance 0 Pain Relevance 0.28
The isolated, spontaneously active portal vein of guinea pig was stimulated by the following compounds (the pD2 is given in parentheses): caerulein (CER, 8.02), cholecystokinin octapeptide (CCK-8, 7.59), substance P (SP, 4.68), and carbachol (5.37), whereas neurotensin (NT) was ineffective and angiotensin II (AII) produced inhibition.
Gene_expression (given) of cholecystokinin octapeptide in portal vein associated with cholecystokinin and substance p
3) Confidence 0.01 Published 1987 Journal Pharmacology Section Abstract Doc Link 2437599 Disease Relevance 0 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools