INT239539

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.38
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (CXCR2, CALCRL) plasma membrane (CXCR2, CALCRL) endosome (CALCRL)
endoplasmic reticulum (CALCRL) intracellular (CXCR2) protein transporter activity (CALCRL)
CXCR2 (Homo sapiens)
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 57 100.00 Very High Very High Very High
agonist 57 95.60 Very High Very High Very High
antagonist 39 92.96 High High
Enkephalin 15 88.00 High High
chemokine 45 85.88 High High
opiate 3 80.12 Quite High
Opioid 15 72.68 Quite High
Cannabinoid 6 54.80 Quite High
Potency 9 52.36 Quite High
MU agonist 24 51.16 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 24 84.24 Quite High
Infection 3 81.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 81.16 Quite High
Obesity 3 51.44 Quite High
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Stomatitis 3 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore our initial studies centred on obtaining evidence for physical interactions between the CXCR2 receptor and the DOP opioid receptor.
CXCR2 receptor Binding (interactions) of receptor associated with opioid receptor
1) Confidence 0.00 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.29 Pain Relevance 0.55
Although the CXCR1 receptor was originally reported not to homodimerize or to heterodimerize with the CXCR2 receptor [24], Wilson et al. [21] recently employed a wide range of biochemical and biophysical approaches to demonstrate the capacity of both CXCR1 and CXCR2 to homodimerize and to show that these two GPCRs were able to form heterodimers as effectively as homodimers.
CXCR2 receptor Binding (heterodimerize) of receptor
2) Confidence 0.00 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.08
This is despite the CXCR2 ligand having no significant affinity to interact directly with the DOP receptor.


CXCR2 Neg (no) Binding (interact) of receptor
3) Confidence 0.00 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.08 Pain Relevance 0.35

General Comments

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