INT23954

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Context Info
Confidence 0.49
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 11.27
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mb)
Anatomy Link Frequency
muscle 4
blood 1
chest 1
band 1
body 1
Mb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 14 99.88 Very High Very High Very High
cva 5 99.84 Very High Very High Very High
Pain 14 99.02 Very High Very High Very High
Enkephalin 4 94.80 High High
ischemia 13 90.72 High High
anesthesia 9 89.84 High High
Catecholamine 3 86.56 High High
Inflammation 9 82.00 Quite High
Spontaneous pain 1 81.96 Quite High
Serotonin 1 78.00 Quite High
Disease Link Frequency Relevance Heat
Injury 15 100.00 Very High Very High Very High
Fasciculation 1 100.00 Very High Very High Very High
Emergencies 7 99.98 Very High Very High Very High
Angina 9 99.88 Very High Very High Very High
Cv General 3 Under Development 6 99.84 Very High Very High Very High
Rhabdomyolysis 12 99.64 Very High Very High Very High
Myalgia 4 99.36 Very High Very High Very High
Acute Coronary Syndrome 5 99.08 Very High Very High Very High
Pain 10 99.02 Very High Very High Very High
Myocardial Infarction 37 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the children without SCH (group 3) no changes could be observed; following SCH (group 2) the mean concentration increased to 1,610.5 ng X ml-1 after 30 min; additional premedication with dantrolene (group 1) led to a significant reduction of the myoglobin concentration (413.7 ng X ml-1; p = 0.031).
Negative_regulation (reduction) of myoglobin
1) Confidence 0.49 Published 1985 Journal Anaesthesist Section Abstract Doc Link 4073445 Disease Relevance 0 Pain Relevance 0.15
A decrease in the level of autoantibodies to myoglobin was observed up to the 18th day of disease.
Negative_regulation (decrease) of myoglobin associated with disease
2) Confidence 0.42 Published 1987 Journal Ter. Arkh. Section Abstract Doc Link 3629507 Disease Relevance 0.78 Pain Relevance 0.13
This can be achieved using myoglobin, creatine kinase and its MB isoenzyme and the cardiac troponins, cardiac troponin T and cardiac troponin I within 4-12 hours of admission, depending on the markers selected.
Negative_regulation (using) of myoglobin
3) Confidence 0.37 Published 1999 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 10389204 Disease Relevance 0.70 Pain Relevance 0.17
[Evaluation of a new commercial kit for emergency determination of serum myoglobin].
Negative_regulation (determination) of serum myoglobin associated with emergencies
4) Confidence 0.37 Published 1994 Journal Ann. Biol. Clin. (Paris) Section Title Doc Link 7998674 Disease Relevance 0.68 Pain Relevance 0.09
Her body temperature and serum CK and Mb levels decreased for a while after administration of dantrolene, but they increased again thereafter.
Negative_regulation (decreased) of Mb in body
5) Confidence 0.35 Published 2005 Journal Masui Section Abstract Doc Link 15717469 Disease Relevance 1.03 Pain Relevance 0.28
STUDY OBJECTIVE: To determine if pretreatment with either gallamine or mivacurium before succinylcholine in children is associated with reduction in fasciculations; postoperative myalgias; or serum levels of potassium, creatinine phosphokinase (CPK), and myoglobin.
Negative_regulation (reduction) of myoglobin associated with fasciculation
6) Confidence 0.34 Published 2001 Journal J Clin Anesth Section Abstract Doc Link 11435054 Disease Relevance 0.10 Pain Relevance 0
Given that the present “10 nsec” model for dimer S-MB in Fig. 11B was developed with MD simulation conditions approximating those of our SDS-PAGE experiments, this structure may also be responsible for the dimer band observed in our electrophoresis studies (Fig. 8).
Negative_regulation (developed) of dimer S-MB in band
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0
Serial determination of myoglobin concentration and creatine kinase in 18 patients with proven acute myocardial infarction showed in general an equal diagnostic significance for both analytes.
Negative_regulation (determination) of myoglobin associated with myocardial infarction
8) Confidence 0.28 Published 1994 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 7888482 Disease Relevance 0.26 Pain Relevance 0.08
In the first 4 hours after onset of chest pain, the determination of myoglobin can have an advantage, since it is released into the blood stream at an earlier stage, but thereafter myoglobin can lead to false negative diagnosis.
Negative_regulation (determination) of myoglobin in blood associated with angina
9) Confidence 0.28 Published 1994 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 7888482 Disease Relevance 0.27 Pain Relevance 0.10
The 1- and 2-g doses reduced postexercise serum hypoxanthine, serum xanthine oxidase, serum myoglobin, and perceived muscle soreness.
Negative_regulation (reduced) of myoglobin in muscle associated with myalgia
10) Confidence 0.20 Published 2007 Journal J Strength Cond Res Section Abstract Doc Link 17313301 Disease Relevance 0.34 Pain Relevance 0
[Role of the serial determination of myoglobin, enzymes and isoenzymes in the early diagnosis of myocardial infarction].
Negative_regulation (determination) of myoglobin associated with myocardial infarction
11) Confidence 0.19 Published 1982 Journal Kardiologiia Section Title Doc Link 7098273 Disease Relevance 0.27 Pain Relevance 0.07
Therefore, the effect of infarct reperfusion on the times to peak value of myoglobin, CKMB, and CK were studied in patients with acute myocardial infarction.
Negative_regulation (value) of myoglobin associated with myocardial infarction
12) Confidence 0.19 Published 1988 Journal Eur. Heart J. Section Abstract Doc Link 3409892 Disease Relevance 0.32 Pain Relevance 0.13
Post-exercise serum creatine kinase activities and myoglobin concentrations were unaffected by supplementation.
Neg (unaffected) Negative_regulation (unaffected) of myoglobin
13) Confidence 0.11 Published 2001 Journal Int J Sport Nutr Exerc Metab Section Abstract Doc Link 11915781 Disease Relevance 0.09 Pain Relevance 0
Post-exercise serum creatine kinase activities and myoglobin concentrations were unaffected by supplementation.
Neg (unaffected) Negative_regulation (unaffected) of myoglobin
14) Confidence 0.11 Published 2003 Journal Eur. J. Appl. Physiol. Section Abstract Doc Link 12682838 Disease Relevance 0.10 Pain Relevance 0
Several days after admission, swelling and pain of calf-muscles began to improve, and serum CK, myoglobin and aldolase decreased rapidly.
Negative_regulation (decreased) of myoglobin in muscles associated with pain and pressure and volume under development
15) Confidence 0.10 Published 1989 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2598545 Disease Relevance 1.37 Pain Relevance 0.32
Especially in insulin resistant diabetes, impaired muscle strength and mass is likely to be associated with the reduction in myoglobin associated with low T levels.


Negative_regulation (reduction) of myoglobin in muscle associated with diabetes mellitus
16) Confidence 0.07 Published 2008 Journal Cardiovasc Diabetol Section Body Doc Link PMC2576082 Disease Relevance 0.47 Pain Relevance 0.04
The accelerated critical pathway for chest pain evaluation was analyzed for: (1) accuracy in triaging of patients within 90 minutes of presentation, (2) sensitivity, specificity, positive predictive value, and negative predictive value of cTnI, myoglobin, and CK-MB in diagnosing acute myocardial infarction (MI) within 90 minutes, and (3) impact on Coronary Care Unit (CCU) admissions.
Negative_regulation (value) of myoglobin in chest associated with angina and myocardial infarction
17) Confidence 0.07 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11564382 Disease Relevance 0.90 Pain Relevance 0.40
As early as in the graphical RKG-RCG period a close inverse correlation could be established between the LV-EF and the serum myoglobin level during the acute course of myocardial infarction, in 10 patients in repeated follow up examinations.
Negative_regulation (established) of serum myoglobin associated with myocardial infarction
18) Confidence 0.05 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3618251 Disease Relevance 0.41 Pain Relevance 0.08
[Early prediction of infarct size by serial determination of serum myoglobin (author's transl)].
Negative_regulation (determination) of serum myoglobin
19) Confidence 0.04 Published 1981 Journal Z Kardiol Section Title Doc Link 7269733 Disease Relevance 0.18 Pain Relevance 0.08
Similarly, the repeated absence of the muscle proteins, desmin and myoglobin, in contrast to a previous report, is interpreted as evidence against a myogenic origin.
Negative_regulation (absence) of myoglobin in muscle
20) Confidence 0.03 Published 1987 Journal Cancer Section Abstract Doc Link 2438029 Disease Relevance 0.70 Pain Relevance 0.38

General Comments

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