INT23955

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Context Info
Confidence 0.25
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 14.21
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vim) structural molecule activity (Vim) plasma membrane (Vim)
cytoskeleton (Vim) nucleus (Vim) biological_process (Vim)
Anatomy Link Frequency
smooth muscle 3
neuronal 1
Neuron 1
fibroblast 1
Vim (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 8 99.88 Very High Very High Very High
cerebral cortex 2 99.84 Very High Very High Very High
headache 4 96.16 Very High Very High Very High
Serotonin 1 96.00 Very High Very High Very High
Inflammation 8 92.68 High High
imagery 18 92.64 High High
Enkephalin 4 92.48 High High
Glutamate 8 89.36 High High
cva 3 88.24 High High
lumbar region 1 83.44 Quite High
Disease Link Frequency Relevance Heat
Meningioma 16 99.96 Very High Very High Very High
Fibrosis 17 99.88 Very High Very High Very High
Sarcoma 13 99.78 Very High Very High Very High
Cancer 103 99.76 Very High Very High Very High
Skin Cancer 66 98.96 Very High Very High Very High
Chordoma 4 98.96 Very High Very High Very High
Cicatrix 2 98.56 Very High Very High Very High
Desmoid Disease 1 98.24 Very High Very High Very High
Hemangiopericytoma 4 97.72 Very High Very High Very High
Gastrointestinal Stromal Tumor 24 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S3) also revealed no age-dependent change in vimentin at the protein level (Fig. 7B).
Neg (no) Regulation (change) of vimentin
1) Confidence 0.25 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical studies revealed immunoreactivity for alpha-smooth muscle antigen (alpha-SMA), vimentin, and desmin.
Regulation (immunoreactivity) of vimentin in smooth muscle
2) Confidence 0.23 Published 1997 Journal Surg. Today Section Abstract Doc Link 9086551 Disease Relevance 1.09 Pain Relevance 0.08
Histopathology of both tumors showed features of CCM, immunopositive for epithelial membrane antigen (EMA) and vimentin.
Regulation (immunopositive) of vimentin associated with meningioma and cancer
3) Confidence 0.23 Published 2009 Journal J Cancer Res Ther Section Abstract Doc Link 20160375 Disease Relevance 1.12 Pain Relevance 0.09
The tumor cells were immunoreactive for vimentin and epithelial membrane antigen.
Regulation (immunoreactive) of vimentin associated with cancer
4) Confidence 0.20 Published 2008 Journal Journal of neurosurgery. Pediatrics Section Abstract Doc Link 18831662 Disease Relevance 1.23 Pain Relevance 0.24
Consistent with the observations from the Masson's trichrome stained sections, there was no age-dependent change in vimentin mRNA and protein (fibroblast marker; Fig. 7) and, in fact, there was a decrease in collagen protein as measured by Picro Sirius red (Fig. 7B).
Regulation (change) of vimentin mRNA in fibroblast
5) Confidence 0.11 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.13 Pain Relevance 0.04
However, there was no age-dependent change in vimentin mRNA (Fig. 7A).
Regulation (change) of vimentin mRNA
6) Confidence 0.11 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0
This treatment induced hyperphosphorylation of neurofilaments, the neuronal intermediate filament (IF) proteins, of heavy, medium and low molecular weight (NF-H, NF-M and NF-L, respectively) without altering the phosphorylation level of astrocyte IF proteins, glial fibrillary acidic protein (GFAP) and vimentin in cerebral cortex of rats.
Neg (without) Regulation (altering) of vimentin in neuronal associated with cerebral cortex
7) Confidence 0.11 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.16
Furthermore, the immunocontent of GFAP and NF subunits was down-regulated, while vimentin was unaltered both in tissue homogenate and in cytoskeletal fraction of hypothyroid animals.
Regulation (unaltered) of vimentin
8) Confidence 0.11 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.17
Immunocytochemistry studies revealed positivity for HMB-45, vimentin and S-100 (Fig. 2).
Regulation (positivity) of vimentin
9) Confidence 0.07 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2607274 Disease Relevance 0.95 Pain Relevance 0
Immunocytochemistry was positive for HMB-45, vimentin and S-100.
Regulation (positive) of vimentin
10) Confidence 0.07 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2607274 Disease Relevance 1.17 Pain Relevance 0.15
Immunohistochemistry demonstrated positivity for vimentin, muscle-specific actin, smooth muscle actin, and cytokeratin consistent with myofibroblasts.
Regulation (positivity) of vimentin in smooth muscle
11) Confidence 0.06 Published 1995 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 7611533 Disease Relevance 1.55 Pain Relevance 0.21
The neoplastic cells were immunopositive for vimentin and epithelial membrane antigen, but immunonegative for S-100 protein and chromogranin A.
Regulation (immunopositive) of vimentin
12) Confidence 0.05 Published 2004 Journal APMIS Section Abstract Doc Link 15056231 Disease Relevance 0.69 Pain Relevance 0.11
Immunohistochemistry with avidin-biotin peroxidase technique showed positivity for CK, S-100 protein, CEA, vimentin and to EMA.
Regulation (positivity) of vimentin
13) Confidence 0.04 Published 1995 Journal Arq Neuropsiquiatr Section Abstract Doc Link 8585826 Disease Relevance 0.42 Pain Relevance 0.12
Even after the detection of the mesenteric primary, the patient was initially treated as a mesenteric sarcoma as histopathology showed a sarcoma which was positive for CD34 and vimentin antigen.
Regulation (positive) of vimentin associated with sarcoma
14) Confidence 0.04 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1654154 Disease Relevance 1.53 Pain Relevance 0.11
In contrast, the stromal component was positive for vimentin, CD10 and, focally, for alpha smooth muscle actin.
Regulation (positive) of vimentin in smooth muscle
15) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1420311 Disease Relevance 0.54 Pain Relevance 0.04
Except for weak vimentin immunoreactivity, no other antigenic expression was detected despite multiple repeated experiments with several antibodies.
Regulation (detected) of vimentin
16) Confidence 0.03 Published 1987 Journal Cancer Section Abstract Doc Link 2438029 Disease Relevance 0.87 Pain Relevance 0.40
Hemangiopericytoma is one of the lesions that bears a close resemblance with SFT of soft tissues (fascicular pattern, fibrosis, and vimentin, CD34, and bcl2 immunoreactivity).
Regulation (immunoreactivity) of vimentin associated with fibrosis and hemangiopericytoma
17) Confidence 0.02 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1913496 Disease Relevance 0.90 Pain Relevance 0.05
Immunohistochemical staining is typically positive for S-100, Vimentin and Neuron-specific enolase.
Regulation (positive) of Vimentin in Neuron
18) Confidence 0.01 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2645401 Disease Relevance 1.25 Pain Relevance 0.07

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