INT239551

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
Anatomy Link Frequency
lymphocytes 1
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 70 100.00 Very High Very High Very High
agonist 19 89.60 High High
opioid receptor 19 51.08 Quite High
cytokine 31 50.00 Quite Low
Cannabinoid 2 44.00 Quite Low
antagonist 14 41.04 Quite Low
rheumatoid arthritis 6 31.60 Quite Low
Potency 3 29.76 Quite Low
Multiple sclerosis 2 29.12 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 5 50.00 Quite Low
Systemic Lupus Erythematosus 35 32.00 Quite Low
Rheumatoid Arthritis 6 31.60 Quite Low
Obesity 1 31.60 Quite Low
Demyelinating Disease 2 29.12 Quite Low
Delirium 13 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Bordatella Infection 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Autoimmune Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, in cells co-expressing the CCR2b and CCR5 chemokine receptors CCR5-specific ligands that are unable to compete for MCP-1 binding on cells expressing CCR2b alone, and hence presumable do not bind directly to CCR2b, were able to prevent efficiently MCP-1 binding when the two receptors were co-expressed [26].
CCR2b Neg (not) Binding (bind) of associated with chemokine
1) Confidence 0.39 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.15
It is a high-affinity ligand for the CCR2 chemokine receptor, that is, constitutively expressed in monocytes but is expressed on lymphocytes only after stimultion by IL-2.
CCR2 chemokine receptor Binding (ligand) of in lymphocytes associated with chemokine
2) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0 Pain Relevance 0.37

General Comments

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