INT23956

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.84
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DES) cytoskeleton (DES) intracellular (DES)
cytoskeleton organization (DES) cytoplasm (DES)
Anatomy Link Frequency
stromal cells 3
muscle 3
smooth muscle 1
filament 1
DES (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 50 100.00 Very High Very High Very High
acular 21 98.20 Very High Very High Very High
Enkephalin 4 94.80 High High
Pain 49 90.20 High High
Eae 14 82.20 Quite High
Serotonin 1 78.00 Quite High
cINOD 2 73.60 Quite High
Inflammatory response 3 68.00 Quite High
nociceptor 4 61.76 Quite High
cytokine 10 53.76 Quite High
Disease Link Frequency Relevance Heat
Cancer 128 100.00 Very High Very High Very High
Lymphatic System Cancer 3 99.40 Very High Very High Very High
Myalgia 16 99.30 Very High Very High Very High
Rhabdomyosarcoma 8 98.84 Very High Very High Very High
Renal Disease 5 98.52 Very High Very High Very High
Leiomyosarcoma 17 98.48 Very High Very High Very High
Nerve Sheath Neoplasms 9 98.06 Very High Very High Very High
Injury 49 97.64 Very High Very High Very High
Sclerosis 4 95.76 Very High Very High Very High
Endometrial Cancer 3 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the lack of desmin, myogenin and MyoD-1 ruled out rhabdomyosarcoma, while LCA negativity ruled out a diagnosis of lymphoma.
Negative_regulation (lack) of desmin associated with lymphatic system cancer and rhabdomyosarcoma
1) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848680 Disease Relevance 2.34 Pain Relevance 0.07
Our aim was to determine whether eccentric exercise leading to DOMS causes sarcolemmal disruption and loss of desmin in humans.
Spec (whether) Negative_regulation (loss) of desmin associated with myalgia
2) Confidence 0.42 Published 2002 Journal Histochem. Cell Biol. Section Abstract Doc Link 12122444 Disease Relevance 0.87 Pain Relevance 0.03
The stromal cells were diffusely positive for vimentin and muscle specific actin, and focally positive for desmin.
Negative_regulation (positive) of desmin in stromal cells
3) Confidence 0.41 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1635700 Disease Relevance 0.31 Pain Relevance 0
Application of a judicious immunohistochemical panel is useful, especially in the distinction of cervical MPNST from leiomyosarcomas, as the former tumors are generally positive for S100 and vimentin and are negative for desmin, myoglobin and actin [36].
Negative_regulation (negative) of desmin associated with leiomyosarcoma, nerve sheath neoplasms and cancer
4) Confidence 0.41 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1584249 Disease Relevance 1.32 Pain Relevance 0
In animal models of eccentric exercise-induced injury, disruption of the cytoskeleton and the sarcolemma of muscle fibres occurs within the first hour after the exercise, since a rapid loss of staining of desmin, a cytoskeletal protein, and the presence of fibronectin, a plasma and extracellular protein, are observed within the muscle fibres.
Negative_regulation (loss) of desmin in muscle associated with injury
5) Confidence 0.41 Published 2002 Journal Histochem. Cell Biol. Section Abstract Doc Link 12122444 Disease Relevance 0.64 Pain Relevance 0
Immunostaining for desmin was negative, although stains for vimentin and smooth muscle actin were both strongly positive.
Negative_regulation (negative) of desmin in smooth muscle
6) Confidence 0.41 Published 1995 Journal Am J Dermatopathol Section Abstract Doc Link 8599440 Disease Relevance 0.79 Pain Relevance 0.23
We were unable to verify that loss of staining for desmin was a feature of sore muscles.
Negative_regulation (loss) of desmin in muscles
7) Confidence 0.33 Published 2002 Journal Histochem. Cell Biol. Section Abstract Doc Link 12189520 Disease Relevance 0.34 Pain Relevance 0
The tumor cells were Vimentin and CD 10 diffuse positive, focal Actin positive, Desmin, KL 1, CD 34 and S 100 protein-negative. 85% of the tumor cells were PCNA positive and 25 % were Ki 67 positive.
Negative_regulation (positive) of Desmin associated with cancer
8) Confidence 0.18 Published 2004 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 16004219 Disease Relevance 0.73 Pain Relevance 0.09
Similarly, the repeated absence of the muscle proteins, desmin and myoglobin, in contrast to a previous report, is interpreted as evidence against a myogenic origin.
Negative_regulation (absence) of desmin in muscle
9) Confidence 0.18 Published 1987 Journal Cancer Section Abstract Doc Link 2438029 Disease Relevance 0.70 Pain Relevance 0.38
Differential expression analysis of the metastatic and primary tumor samples shows that a large number of the most highly downregulated genes such as TAGLN, ACTG2, TPM1, MYH111 and DES have been previously identified as expressed mostly in the prostatic stromal cells [15].
Negative_regulation (downregulated) of DES in stromal cells associated with cancer
10) Confidence 0.08 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.51 Pain Relevance 0
Differential expression analysis of the metastatic and primary tumor samples shows that a large number of the most highly downregulated genes such as TAGLN, ACTG2, TPM1, MYH111 and DES have been previously identified as expressed mostly in the prostatic stromal cells [15].
Negative_regulation (number) of DES in stromal cells associated with cancer
11) Confidence 0.08 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.51 Pain Relevance 0
In addition, we observed a redistribution of actin cytoskeleton fibers and of the intermediate filament protein nestin.
Negative_regulation (redistribution) of intermediate filament protein in filament
12) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.13 Pain Relevance 0.03
Both BK and des-Arg9-BK levels in microdialysate were detectable at all time points and decreased gradually over the 3 h collection period with the third hour being significantly lower than the first and second hours in both the placebo and ketorolac treatment groups (p < 0.05).
Negative_regulation (decreased) of des-Arg9-BK associated with acular and bradykinin
13) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.65 Pain Relevance 0.99

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