INT2396

Context Info Confidence 0.62 First Reported 1979 Last Reported 2010 Negated 3 Speculated 1 Reported most in Abstract Documents 25 Total Number 27 Disease Relevance 6.04 Pain Relevance 13.27

mitochondrion (Maoa) oxidoreductase activity (Maoa)

Anatomy Link Frequency brain 9 liver 2 cerebrospinal fluid 1 lung 1 Maoa (Mus musculus)

Pain Link Frequency Relevance Heat monoamine 198 100.00 Serotonin 73 100.00 methadone 21 100.00 Morphine 20 100.00 Catecholamine 12 100.00 antidepressant 237 99.64 Clonidine 15 99.16 Dopamine 502 99.06 fluoxetine 57 97.64 Neurotransmitter 27 95.32

Disease Link Frequency Relevance Heat INFLAMMATION 7 100.00 Nicotine Addiction 173 99.82 Convulsion 2 99.80 Depression 197 99.70 Disease 123 99.48 Manic Depressive Disorder 12 96.20 Death 9 95.88 Alagille Syndrome 8 95.20 Anxiety Disorder 12 93.08 Reprotox - General 2 1 91.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effect of morphine, levorphanol and methadone on the monoamine oxidase (MAO) activity of mouse brain was studied.

Regulation (effect) of MAO in brain associated with methadone, monoamine and morphine

1) Confidence 0.62 Published 1979 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 432429 Disease Relevance 0 Pain Relevance 0.76

Anti-convulsant activity of diazepam and clonidine on metaldehyde-induced seizures in mice: effects on brain gamma-amino butyric acid concentrations and monoamine oxidase activity.

Regulation (effects) of monoamine oxidase in brain associated with convulsion, monoamine and clonidine

2) Confidence 0.62 Published 1982 Journal J. Vet. Pharmacol. Ther. Section Title Doc Link 7143555 Disease Relevance 0.29 Pain Relevance 0.44

Moreover, results obtained in two species (human and mice), with three cell types (platelets, PBMC, lung cells) and concerning both MAO isoenzymes, indicate that this smoking-induced MAO gene deregulation could have a more general impact than vascular modifications.

Regulation (deregulation) of MAO in lung associated with nicotine addiction

3) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.79 Pain Relevance 0

The effect of morphine, levorphanol and methadone on the monoamine oxidase (MAO) activity of mouse brain was studied.

Regulation (effect) of monoamine oxidase in brain associated with methadone, monoamine and morphine

4) Confidence 0.45 Published 1979 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 432429 Disease Relevance 0 Pain Relevance 0.75

It was shown that monoamine oxidase-B (MAO-B) inhibitors and antiinflammatory agents might be effective in treating AD.

Spec (might) Regulation (effective) of MAO-B associated with inflammation, disease and monoamine

5) Confidence 0.45 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17611112 Disease Relevance 0.75 Pain Relevance 0.16

Effects of RS-2232 on monoamine oxidase (MAO) activities in mouse brain and liver were investigated with 5-hydroxytryptamine (5-HT), beta-phenyl-ethylamine (PEA), and in some cases, kynuramine as substrate.

Regulation (Effects) of MAO in brain associated with monoamine

6) Confidence 0.45 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3682407 Disease Relevance 0 Pain Relevance 0.09

Effects of RS-2232 on monoamine oxidase (MAO) activities in mouse brain and liver were investigated with 5-hydroxytryptamine (5-HT), beta-phenyl-ethylamine (PEA), and in some cases, kynuramine as substrate.

Regulation (Effects) of monoamine oxidase in brain associated with monoamine

7) Confidence 0.45 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3682407 Disease Relevance 0 Pain Relevance 0.09

The effectiveness of the MAO inhibitors in blocking the action of the reduced toxins was consistent with their ability to inhibit MAO activity in the cell cultures, but did not reflect MAO-substrate specificity of the toxins.

Regulation (effectiveness) of MAO

8) Confidence 0.44 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1776993 Disease Relevance 0.83 Pain Relevance 0.29

The present study investigated the effects of maze-experience on the acute behavioral effects of the monoamine oxidase inhibitor phenelzine and the serotonin reuptake inhibitor fluoxetine.

Regulation (effects) of monoamine oxidase associated with serotonin, fluoxetine and monoamine

9) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12524150 Disease Relevance 0.22 Pain Relevance 0.41

Effects of adrenergic and cholinergic stimulation on islet monoamine oxidase activity and insulin secretion in the mouse.

Regulation (Effects) of islet monoamine oxidase associated with monoamine

10) Confidence 0.41 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.74

Cholinergic muscarinic stimulation by a maximal insulin releasing dose of carbachol did not affect islet monoamine oxidase activity.

Neg (not) Regulation (affect) of islet monoamine oxidase associated with monoamine

11) Confidence 0.41 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.84

These effects on insulin secretion and monoamine oxidase activity could not be blocked by clonidine.

Regulation (effects) of monoamine oxidase associated with clonidine and monoamine

12) Confidence 0.41 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.05

The MAOA and MAOB genes are located on the X chromosome (Xp11) [63] and code for enzymes that catalyze the deamination of biogenic amines including the neurotransmitters norephinephrine, dopamine and serotonin.

Regulation (located) of MAOA associated with dopamine, neurotransmitter and serotonin

13) Confidence 0.39 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.48 Pain Relevance 0.56

Similarly, no locomotor effect of MAO-A or MAO-B inhibitors was observed in these mice, indicating that the locomotor effect of amphetamines may not be explained by MAO-inhibitory action [38].

Neg (no) Regulation (effect) of MAO

14) Confidence 0.36 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.05 Pain Relevance 0.58

Similarly, no locomotor effect of MAO-A or MAO-B inhibitors was observed in these mice, indicating that the locomotor effect of amphetamines may not be explained by MAO-inhibitory action [38].

Neg (no) Regulation (effect) of MAO

15) Confidence 0.36 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.05 Pain Relevance 0.58

Effect of narcotics on monoamine oxidase activity of mouse brain.

Regulation (Effect) of monoamine oxidase in brain associated with monoamine

16) Confidence 0.27 Published 1979 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 432429 Disease Relevance 0 Pain Relevance 1.13

The effects of these drugs individually and in combination on brain MAO-A and MAO-B activity and 5-HT uptake were also determined ex vivo and were consistent with expected mechanisms of action.

Regulation (effects) of MAO in brain

17) Confidence 0.23 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.92 Pain Relevance 0.19

Effect of Garlic extract on brain monoamine oxidase (MAO) activity

Regulation (Effect) of monoamine oxidase in brain associated with monoamine

18) Confidence 0.21 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792615 Disease Relevance 0 Pain Relevance 0.36

For example, reduced monoamine metabolite levels have been found in the cerebrospinal fluid of depressed individuals; likewise, serotonin (5-HT), norepinephrine or dopamine depletion exerts pro-depressive effects.[2–3] Monoamine oxidase (MAO) is responsible for metabolizing monoamines like norepinephrine, dopamine and 5-HT.

Regulation (responsible) of Monoamine oxidase in cerebrospinal fluid associated with dopamine, depression, serotonin and monoamine

19) Confidence 0.21 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792615 Disease Relevance 0.57 Pain Relevance 1.01

MAO-A has substrate preference for serotonin and is the main target for the antidepressant monoamine oxidase inhibitors.

Regulation (target) of MAO associated with antidepressant, serotonin and monoamine

20) Confidence 0.21 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792615 Disease Relevance 0.61 Pain Relevance 1.13

General Comments

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