INT239610

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ1) transmembrane transport (KCNQ1)
Anatomy Link Frequency
neuronal 1
heart 1
KCNQ1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anticonvulsant 2 95.28 Very High Very High Very High
sodium channel 24 89.08 High High
action potential duration 21 84.52 Quite High
Calcium channel 3 64.24 Quite High
Action potential 66 49.20 Quite Low
potassium channel 10 19.68 Low Low
Spinal cord 8 9.56 Low Low
lidocaine 9 5.00 Very Low Very Low Very Low
Mexiletine 6 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 139 100.00 Very High Very High Very High
Cv General 2 Under Development 2 99.16 Very High Very High Very High
Symphalangism 3 96.72 Very High Very High Very High
Malignant Neoplastic Disease 4 91.28 High High
Cv General 4 Under Development 2 78.96 Quite High
Arrhythmias 2 Under Development 8 74.88 Quite High
Hypoglycemia 1 74.24 Quite High
Cognitive Disorder 1 73.12 Quite High
Congenital Anomalies 8 72.32 Quite High
Autism 2 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LQT8 is a rare variant of LQTS characterized by marked QT interval prolongation, often presenting with 2:1 functional atrioventricular block and macroscopic T wave alternans, and syndactyly.
Localization (presenting) of LQT8 associated with symphalangism, cv general 2 under development and syndrome
1) Confidence 0.62 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.21 Pain Relevance 0.15
The beneficial effects of chromanol were evaluated in the intact canine heart and it was found that blockage of IKs produced a spatially uniform increase in ERPs that, unlike blockage of IKr by dofetilide, became more pronounced at higher heart rates (Bauer et al. 1999).
Localization (blockage) of IKs in heart
2) Confidence 0.49 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.26 Pain Relevance 0
Natural selection based on the physiological advantages conferred by colocalization of NaV and KCNQ channels, and partial sequence convergence, is a plausible alternative mechanism to transfer of the preexisting NaV motif and divergence.
Localization (colocalization) of KCNQ
3) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0
Invertebrate KCNQ sequences fell into two groups, one with SID sequences like mammalian KCNQ1 (honey bee Apis mellifera KCNQ, Caenorhabditis elegans KQT-3, and C. intestinalis KCNQ1) (Figure 2F, yellow shading) and the other with sequences intermediate between KCNQ1 and the mammalian neuronal KCNQs (e.g., D. melanogaster KCNQ, C. elegans KQT-1, and the beetle Tribolium castaneum KCNQ).
Localization (beetle) of KCNQ in neuronal
4) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.05

General Comments

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