INT2397

Context Info Confidence 0.77 First Reported 1979 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 12 Total Number 14 Disease Relevance 11.85 Pain Relevance 3.88

mitochondrion (Maoa) oxidoreductase activity (Maoa)

Anatomy Link Frequency neuronal 2 platelet 2 central nervous system 2 neurons 1 brain 1 Maoa (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 68 100.00 monoamine 50 100.00 methadone 7 99.98 Morphine 6 98.32 Central nervous system 4 97.36 Raphe 8 94.16 Dopamine 17 91.56 Neurotransmitter 10 90.88 agonist 13 90.44 narcan 1 84.92

Disease Link Frequency Relevance Heat Nicotine Addiction 513 99.68 Urological Neuroanatomy 7 99.52 Toxicity 12 99.40 Neuroblastoma 4 99.14 Parkinson's Disease 32 98.72 Chronic Fatigue Syndrome 83 98.50 Aggression 138 98.04 Disease 31 94.64 INFLAMMATION 10 93.00 Apoptosis 5 84.24

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Unlike previously reported studies with cultured cells of neuronal origin expressing only MAO A, both of these cell lines were sensitive to MPTP.

Gene_expression (expressing) of MAO in neuronal associated with parkinson's disease

1) Confidence 0.77 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1776993 Disease Relevance 0.77 Pain Relevance 0.13

The toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), its oxidized metabolite, and two recently synthesized 2'-alkyl derivatives of MPTP (methyl and ethyl), found to be more toxic in vivo in mice, have been compared in two neuroblastoma hybrid cell lines (NCB-20 and 140-3) that express the B form of monoamine oxidase (MAO), as tissue culture models for the mode of action of MPTP in the central nervous system.

Gene_expression (express) of MAO in central nervous system associated with parkinson's disease, neuroblastoma, toxicity, central nervous system and monoamine

2) Confidence 0.77 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1776993 Disease Relevance 0.79 Pain Relevance 0.14

The toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), its oxidized metabolite, and two recently synthesized 2'-alkyl derivatives of MPTP (methyl and ethyl), found to be more toxic in vivo in mice, have been compared in two neuroblastoma hybrid cell lines (NCB-20 and 140-3) that express the B form of monoamine oxidase (MAO), as tissue culture models for the mode of action of MPTP in the central nervous system.

Gene_expression (express) of monoamine oxidase in central nervous system associated with parkinson's disease, neuroblastoma, toxicity, central nervous system and monoamine

3) Confidence 0.77 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1776993 Disease Relevance 0.79 Pain Relevance 0.14

Toxicity of MPTP and structural analogs in clonal cell lines of neuronal origin expressing B type monoamine oxidase activity.

Gene_expression (expressing) of monoamine oxidase in neuronal associated with parkinson's disease, toxicity and monoamine

4) Confidence 0.67 Published 1991 Journal Mol. Chem. Neuropathol. Section Title Doc Link 1776993 Disease Relevance 0.81 Pain Relevance 0.19

MAO activity and MAO protein concentration were therefore measured in platelets since this is the most easily accessible source of MAO.

Gene_expression (source) of MAO in platelets

5) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 2.31 Pain Relevance 0.04

It thus appears that MAO inhibition during smoking was compensated by a higher synthesis.

Neg (inhibition) Gene_expression (inhibition) of MAO associated with nicotine addiction

6) Confidence 0.66 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2775922 Disease Relevance 1.59 Pain Relevance 0.10

Therefore, a novel series of 1-thiocarbamoyl-3-substituted phenyl-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole derivatives as promising MAO-B inhibitors was synthesized and investigated for the ability to inhibit selectively the activity of the A and B isoforms of monoamine oxidase (MAO).

Spec (investigated) Gene_expression (synthesized) of MAO-B associated with monoamine

7) Confidence 0.60 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17611112 Disease Relevance 0.80 Pain Relevance 0.23

Unexpectedly however, the platelet MAO protein concentration was also higher in S (Fig. 1D).

Gene_expression (concentration) of MAO protein in platelet

8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.38 Pain Relevance 0.03

Methadone produced a slight but significant inhibition of whole brain MAO and a 34% inhibition of the striatal enzyme.

Gene_expression (produced) of MAO in brain associated with methadone

9) Confidence 0.53 Published 1979 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 432429 Disease Relevance 0 Pain Relevance 1.28

Subclasses of CFS have been associated with polymorphisms in genes that function in the HPA axis NR3C1, TPH2 and MAOA [37-39].

Gene_expression (axis) of MAOA associated with chronic fatigue syndrome

10) Confidence 0.36 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 1.28 Pain Relevance 0.24

We examined the expression of several 5-HT receptors and the enzyme monoamine oxidase (MAO-A) in frontal cortex of Gtf2ird1?

Spec (examined) Gene_expression (expression) of monoamine oxidase in frontal cortex associated with urological neuroanatomy and monoamine

11) Confidence 0.30 Published 2010 Journal J Neurodev Disord Section Body Doc Link PMC2882561 Disease Relevance 0.35 Pain Relevance 0.29

In contrast, MAOA deficiency in humans [17] and mice [18] leads to increased aggression, despite the resulting increase in 5-HT levels.

Gene_expression (deficiency) of MAOA associated with aggression

12) Confidence 0.14 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1564424 Disease Relevance 0.67 Pain Relevance 0.25

These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.

Gene_expression (express) of monoamine oxidase in neurons associated with serotonin and monoamine

13) Confidence 0.13 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.40

Moreover, monoamine oxidase-A (MAO-A) expression is regulated by dimer formation of Clock and Bmal1, and MAO-A activity accordingly shows a circadian rhythmicity [118].

Gene_expression (expression) of monoamine oxidase associated with monoamine

14) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.24 Pain Relevance 0.43

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