INT239779

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.48
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
heart 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 100.00 Very High Very High Very High
ischemia 3 75.04 Quite High
metalloproteinase 6 73.68 Quite High
Paracetamol 1 71.44 Quite High
agonist 20 68.40 Quite High
addiction 2 50.00 Quite Low
potassium channel 9 9.52 Low Low
imagery 7 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 100.00 Very High Very High Very High
Coronary Heart Disease 4 95.16 Very High Very High Very High
Stress 28 91.20 High High
Diabetes Mellitus 29 78.04 Quite High
Sprains And Strains 27 76.20 Quite High
Coronary Artery Disease 3 75.68 Quite High
Shock 151 72.40 Quite High
Atherosclerosis 2 69.20 Quite High
Reprotox - General 1 1 69.16 Quite High
Toxicity 8 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using reporter assays, mir-122 was shown to down-regulate PPAR?
Negative_regulation (down) of Regulation (regulate) of PPAR
1) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.07
in this study model may not have been sufficient to prevent steatosis and other effects observed in Ppar?
Negative_regulation (prevent) of Regulation (effects) of Ppar
2) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.21 Pain Relevance 0.03
Exposure to PPC leads to regulation of a large number of genes including up-regulation of those involved in lipid homeostasis and down-regulation of inflammatory genes that are generally abolished in PPC-exposed PPAR?
Negative_regulation (abolished) of Regulation (regulation) of PPAR associated with inflammation
3) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.78 Pain Relevance 0.16
These findings may reflect an indirect effect of rosiligitazone on the heart, as demonstrated by a study in which metabolic changes in PPAR?
Negative_regulation (metabolic) of Regulation (changes) of PPAR in heart
4) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.50 Pain Relevance 0.10

General Comments

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