INT239804

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.09
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HSF1) nucleus (HSF1) protein complex (HSF1)
cytoplasm (HSF1)
HSF1 (Homo sapiens)
HSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 36 95.88 Very High Very High Very High
Immobilon 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 54 99.92 Very High Very High Very High
Shock 201 97.96 Very High Very High Very High
Injury 6 94.80 High High
Death 15 94.36 High High
Cytomegalovirus Infection 6 80.68 Quite High
Targeted Disruption 15 66.52 Quite High
Neurodegenerative Disease 6 43.12 Quite Low
Motor Neuron Diseases 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSF1 mediates the HSR: stress acutely converts the constitutively expressed dormant, monomeric HSF1 in the cytosol to a nuclear localized, hyperphosphorylated HSF1 trimer that binds and trans-activates the heat shock promoters [18].
HSF1 Positive_regulation (mediates) of HSR associated with stress and shock
1) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.38 Pain Relevance 0.05
We show that riluzole increased the amount of HSF1 to amplify the HSR for cytoprotection.
HSF1 Positive_regulation (amplify) of HSR
2) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2481402 Disease Relevance 0.56 Pain Relevance 0
In this context, our observation that riluzole increased HSF1 reserve to allow for a more robust mobilization of HSF1 and induction of the HSR would suggest that riluzole and conditioning heat shock could have synergistic effect in protecting cells against stress-induced injury and death.
HSF1 Positive_regulation (induction) of HSR associated with stress, injury, shock and death
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 1.15 Pain Relevance 0

General Comments

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