INT239816

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HSF1) nucleus (HSF1) protein complex (HSF1)
cytoplasm (HSF1)
Anatomy Link Frequency
body 4
HSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 48 21.48 Low Low
Glutamate 8 5.00 Very Low Very Low Very Low
Immobilon 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 314 99.18 Very High Very High Very High
Stress 112 97.00 Very High Very High Very High
Injury 8 94.36 High High
Death 38 93.92 High High
Apoptosis 22 63.28 Quite High
Targeted Disruption 20 50.16 Quite High
Toxicity 8 42.68 Quite Low
Cancer 22 27.36 Quite Low
Disease 14 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this context, our observation that riluzole increased HSF1 reserve to allow for a more robust mobilization of HSF1 and induction of the HSR would suggest that riluzole and conditioning heat shock could have synergistic effect in protecting cells against stress-induced injury and death.
Positive_regulation (induction) of Localization (mobilization) of HSF1 associated with stress, injury, shock and death
1) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 1.15 Pain Relevance 0
M, 37°C for last 3 hr) or heat shock (42°C for the last 2 hr) gave a greater mobilization and accumulation of the HSF1 in the nuclear compartment (lanes 9–12).
Positive_regulation (accumulation) of Localization (mobilization) of HSF1 associated with shock
2) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.32 Pain Relevance 0
In this context, our observation that riluzole increased HSF1 reserve to allow for a more robust mobilization of HSF1 and induction of the HSR would suggest that riluzole and conditioning heat shock could have synergistic effect in protecting cells against stress-induced injury and death.
Positive_regulation (allow) of Localization (mobilization) of HSF1 associated with stress, injury, shock and death
3) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 1.15 Pain Relevance 0
The effect of riluzole on HSF1 is qualitatively different from that of MG132 and chloroquine, inhibitors of the proteasome and lysosome, respectively; they promoted the hyperphosphorylation, nuclear translocation and activation of HSF1.
Positive_regulation (activation) of Localization (translocation) of HSF1
4) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.05 Pain Relevance 0
Our hypothesis that HNE modification of Hsp70 or Hsp90 leads to the release and activation of HSF1 is supported by a reasonable body of in vitro and in vivo results.19,27–29,40,41 However, it is also possible that modification of other cellular proteins leads to their unfolding, which attracts Hsp90 away from HSF1.
Positive_regulation (leads) of Localization (release) of HSF1 in body
5) Confidence 0.43 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.53 Pain Relevance 0
Our hypothesis that HNE modification of Hsp70 or Hsp90 leads to the release and activation of HSF1 is supported by a reasonable body of in vitro and in vivo results.19,27–29,40,41 However, it is also possible that modification of other cellular proteins leads to their unfolding, which attracts Hsp90 away from HSF1.
Positive_regulation (activation) of Localization (release) of HSF1 in body
6) Confidence 0.43 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.52 Pain Relevance 0

General Comments

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