INT239819

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HSR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 10.88 Low Low
Spinal cord 24 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 134 97.96 Very High Very High Very High
Stress 36 97.00 Very High Very High Very High
Injury 4 94.80 High High
Death 10 94.36 High High
Targeted Disruption 10 64.56 Quite High
INFLAMMATION 2 10.48 Low Low
Motor Neuron Diseases 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this context, our observation that riluzole increased HSF1 reserve to allow for a more robust mobilization of HSF1 and induction of the HSR would suggest that riluzole and conditioning heat shock could have synergistic effect in protecting cells against stress-induced injury and death.
Positive_regulation (allow) of Positive_regulation (induction) of HSR associated with stress, injury, shock and death
1) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 1.16 Pain Relevance 0
Their mechanisms of action likely involve the blockage of bulk protein degradation, leading to the buildup of abnormal, mis-folded proteins and consequently activation of the HSR.
Positive_regulation (leading) of Positive_regulation (activation) of HSR
2) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.06 Pain Relevance 0

General Comments

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