INT23992

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Context Info
Confidence 0.56
First Reported 1980
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 4.01
Pain Relevance 7.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
spleen 2
heart 2
sympathetic 1
Purkinje fibers 1
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
local anesthetic 2 100.00 Very High Very High Very High
lidocaine 2 100.00 Very High Very High Very High
Clonidine 34 99.92 Very High Very High Very High
agonist 37 99.88 Very High Very High Very High
Hyperalgesia 9 99.82 Very High Very High Very High
gABA 20 99.40 Very High Very High Very High
Kinase C 12 98.80 Very High Very High Very High
Catecholamine 6 98.28 Very High Very High Very High
Angina 5 98.28 Very High Very High Very High
antagonist 23 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 9 99.82 Very High Very High Very High
Hypotension 9 99.24 Very High Very High Very High
Cv General 3 Under Development 5 98.28 Very High Very High Very High
Neuropathic Pain 7 96.38 Very High Very High Very High
Diabetes Mellitus 1 95.84 Very High Very High Very High
Heart Rate Under Development 8 94.52 High High
Immunization 7 94.48 High High
Increased Venous Pressure Under Development 2 94.00 High High
Pain 1 93.32 High High
Disease 1 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that antibody responses can be modulated by alpha-1 adrenoceptor activation to produce an enhanced response 1 day sooner than the peak control response and by alpha-2 adrenoceptor activation to produce a depressed response at the time of the peak control response.
Positive_regulation (activation) of adrenoceptor
1) Confidence 0.56 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982010 Disease Relevance 0.07 Pain Relevance 0.17
Alpha-1 adrenoceptor activation by methoxamine produced a number of spleen cells secreting immunoglobulin M antibody which was enhanced 63% above control on day 4 after immunization and which returned to control levels on days 5 (peak day of control antibody response), 6 and 7.
Positive_regulation (activation) of adrenoceptor in spleen associated with immunization
2) Confidence 0.56 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982010 Disease Relevance 0.09 Pain Relevance 0.07
These results suggest that antibody responses can be modulated by alpha-1 adrenoceptor activation to produce an enhanced response 1 day sooner than the peak control response and by alpha-2 adrenoceptor activation to produce a depressed response at the time of the peak control response.
Positive_regulation (activation) of adrenoceptor
3) Confidence 0.56 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982010 Disease Relevance 0.06 Pain Relevance 0.17
The present study shows that positive and negative modulation of the immunoglobulin M antibody response in mouse spleen cells immunized with sheep erythrocytes can be achieved by selective activation of alpha adrenoceptor subtypes.
Positive_regulation (activation) of adrenoceptor in spleen
4) Confidence 0.56 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982010 Disease Relevance 0.09 Pain Relevance 0.06
Activation of central alpha-2 adrenoceptor leads to a sleep-like state.
Positive_regulation (Activation) of adrenoceptor
5) Confidence 0.50 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8930144 Disease Relevance 0.09 Pain Relevance 0.36
These studies indicate that ICI 89,406 produces effective beta-adrenoceptor blockade during exercise in patients with angina pectoris.
Positive_regulation (produces) of beta-adrenoceptor associated with angina
6) Confidence 0.47 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6156341 Disease Relevance 0.49 Pain Relevance 0.49
The high systemic availability of pindolol after oral administration, due to good oral absorption and low first-pass effect, is revealed not only in pharmacokinetic studies but also in pharmacodynamic experiments; beta-adrenoceptor blockade 75 minutes after intravenous administration was equivalent to that observed 2 hours after the same doses given orally.
Positive_regulation (equivalent) of beta-adrenoceptor
7) Confidence 0.45 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 6125094 Disease Relevance 0.09 Pain Relevance 0.03
Partial agonist activity is the intrinsic activity that some drugs have to stimulate the beta adrenoceptor while they are competitively antagonizing catecholamines.
Positive_regulation (stimulate) of beta adrenoceptor associated with catecholamine and agonist
8) Confidence 0.44 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2439820 Disease Relevance 0.70 Pain Relevance 0.32
Alpha-2 adrenoceptor activation by clonidine produced no change when compared to control on days 4, 6 or 7, but produced a 50% suppression on day 5.
Positive_regulation (activation) of adrenoceptor associated with clonidine
9) Confidence 0.37 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982010 Disease Relevance 0.09 Pain Relevance 0.17
Role of alpha adrenoceptor activation in modulating the murine primary antibody response in vitro.
Positive_regulation (activation) of adrenoceptor
10) Confidence 0.37 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2982010 Disease Relevance 0.08 Pain Relevance 0.12
Activation of both adrenoceptor subtypes by phenylephrine produced a control response on day 4, a depressed response on day 5 and an elevated response on days 6 and 7 by 50 and 64% above control, respectively.
Positive_regulation (Activation) of adrenoceptor
11) Confidence 0.37 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982010 Disease Relevance 0.08 Pain Relevance 0.18
Beta-AR activation via isoproterenol (1 microM) results in an increase in excitatory transmission in dBNST, but not in vBNST.
Positive_regulation (activation) of Beta-AR
12) Confidence 0.28 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15602500 Disease Relevance 0.07 Pain Relevance 0.24
In this study, mice with a targeted inactivation of the alpha(2C)-adrenoceptor gene (alpha(2C)-KO mice), and genetically related mice (WT mice), were used to study the potential role of the striatal alpha(2C)-adrenoceptor in modulating GABA release.
Positive_regulation (role) of adrenoceptor associated with gaba
13) Confidence 0.21 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12670699 Disease Relevance 0 Pain Relevance 0.38
The development of neuropathic heat hyperalgesia required the presence of both the alpha(2A) adrenoceptor and the sympathetic postganglionic neuron (SPGN), but the development of mechanical hyperalgesia did not require either the alpha(2A) adrenoceptor or the SPGN, indicating different mechanisms of sensitization.
Neg (not) Positive_regulation (require) of adrenoceptor in sympathetic associated with hyperalgesia and neuropathic pain
14) Confidence 0.21 Published 2000 Journal Pain Section Abstract Doc Link 10781908 Disease Relevance 1.22 Pain Relevance 1.09
In this study, mice with a targeted inactivation of the alpha(2C)-adrenoceptor gene (alpha(2C)-KO mice), and genetically related mice (WT mice), were used to study the potential role of the striatal alpha(2C)-adrenoceptor in modulating GABA release.
Positive_regulation (inactivation) of adrenoceptor associated with gaba
15) Confidence 0.21 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12670699 Disease Relevance 0 Pain Relevance 0.29
Moreover, stimulation of alpha(2)-adrenoceptor by their agonists triggered the activation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway.
Positive_regulation (stimulation) of adrenoceptor associated with agonist
16) Confidence 0.05 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.51
Yohimbine and 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)4,5-dihydro-1H-imidazole (RX821002), alpha(2)-adrenoceptor antagonists, significantly blocked agonist-induced interleukin-12 production and p38 MAPK activation, indicating that the effects of the agonists were mediated through alpha(2)-adrenoceptor.
Positive_regulation (mediated) of adrenoceptor associated with antagonist and agonist
17) Confidence 0.05 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.64
CGS 7525A, a new tetracyclic compound, was evaluated for alpha 2 adrenoceptor antagonism in receptor binding assays and in behavioral and electrophysiological tests. 3H-Clonidine, but not 3H-prazosin, binding was potently inhibited in vitro by CGS 7525A.
Neg (not) Positive_regulation (evaluated) of adrenoceptor associated with clonidine
18) Confidence 0.05 Published 1983 Journal Life Sci. Section Abstract Doc Link 6131367 Disease Relevance 0.06 Pain Relevance 0.32
Modulation of pacemaker activity in sheep cardiac Purkinje fibers by stimulation of beta-adrenoceptor subtypes.
Positive_regulation (stimulation) of beta-adrenoceptor in Purkinje fibers
19) Confidence 0.04 Published 1997 Journal Basic Res. Cardiol. Section Title Doc Link 9062649 Disease Relevance 0 Pain Relevance 0.59
Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor.
Positive_regulation (enhances) of adrenoceptor associated with lidocaine and local anesthetic
20) Confidence 0.03 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18635472 Disease Relevance 0 Pain Relevance 0.61

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