INT239952

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
muscle cells 2
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 40 96.38 Very High Very High Very High
imagery 8 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 28 86.80 High High
Hypoxia 2 84.00 Quite High
Apoptosis 2 74.88 Quite High
Necrosis 2 65.84 Quite High
Chronic Disease 2 63.68 Quite High
Muscular Dystrophy 12 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Muscle Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taking into account that currents in cell-attached patches were completely blocked by TTX, we confirm that Nav1.4 is the primary isoform expressed in the sarcolemma of both dystrophic and control fibers and that the up-regulated activity of Nav1.4 channels is primarily responsible for the increase in Na+ influx in dystrophin-deficient muscle cells, significantly affecting their survival.
Regulation (responsible) of Positive_regulation (increase) of Na in muscle cells associated with tetrodotoxin
1) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.38 Pain Relevance 0.43
Thus, the reduced expression levels of Nav1.4 channels might be explained by a compensatory mechanism down-regulating, via the E box motif, their expression in response to the increase in Na+ influx via VGSCs.
Regulation (response) of Positive_regulation (increase) of Na
2) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.18 Pain Relevance 0

General Comments

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