INT239955

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.78
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp2a1) endoplasmic reticulum (Atp2a1)
Anatomy Link Frequency
muscles 1
heart 1
reticulum 1
Atp2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 10 84.24 Quite High
tetrodotoxin 60 68.08 Quite High
Central nervous system 3 66.32 Quite High
imagery 14 5.00 Very Low Very Low Very Low
sodium channel 9 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 26 84.24 Quite High
Hypoxia 29 83.76 Quite High
Myocardial Infarction 9 82.96 Quite High
Synkinesis 3 75.76 Quite High
Breast Cancer 2 60.56 Quite High
Cancer 4 51.32 Quite High
Paralysis 15 47.60 Quite Low
Hyperplasia 2 43.56 Quite Low
Targeted Disruption 24 35.44 Quite Low
Death 46 6.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of calsequestrin and sarcoendoplasmic reticulum Ca2+-ATPase 1 (SERCA1)
Gene_expression (analysis) of SERCA1 in reticulum
1) Confidence 0.29 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0 Pain Relevance 0
Western blot analysis of SERCA1 expression was performed using mouse anti-SERCA1 antibody (Affinity Bioreagents 1:1,000).
Gene_expression (expression) of SERCA1
2) Confidence 0.28 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.06
Expression of SERCA1 has been shown to be essentially the same in FDB muscles from C57BL/6J and mdx5cv mice (Boittin et al., 2006).


Gene_expression (Expression) of SERCA1 in muscles
3) Confidence 0.28 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.07
Proteins were detected by chemiluminescence using the ECL plus kit (Amersham Biosciences) on Fuji x-ray film, and were quantified using the Bio-Rad Laboratories Inc. scanner (Universal Hood II, Quantity one analysis software) and normalized to expression level of SERCA1.
Gene_expression (expression) of SERCA1
4) Confidence 0.28 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.06
However, no significant difference was observed between the three groups with respect to SERCA1 expression (Fig. 2).


Gene_expression (expression) of SERCA1
5) Confidence 0.26 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.08 Pain Relevance 0.03
Ryanodine binding assays were performed, and Ca2+ uptake rates, calsequestrins and SERCA levels were determined.
Gene_expression (levels) of SERCA
6) Confidence 0.23 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2687630 Disease Relevance 0 Pain Relevance 0
We propose that the heart cannot maintain normal contractility because of reduced expression of the SERCA pump, with resulting slowed re-uptake of cytoplasmic Ca++.
Gene_expression (expression) of SERCA in heart
7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.54 Pain Relevance 0.04
The abundance of cardiac SERCA mRNA was reduced 2-fold after 3 days of transgene expression and SERCA protein was reduced to an even greater degree (Figure 10).
Gene_expression (expression) of SERCA
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.16 Pain Relevance 0

General Comments

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