INT23998

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.51
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
SH-SY5Y 1
P19 1
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 21 100.00 Very High Very High Very High
opioid receptor 20 99.80 Very High Very High Very High
intrathecal 1 96.32 Very High Very High Very High
Antinociceptive 2 90.00 High High
tail-flick 1 86.56 High High
Neurotransmitter 5 80.92 Quite High
antagonist 2 78.40 Quite High
antinociception 1 77.84 Quite High
Morphine 4 73.16 Quite High
Analgesic 3 70.44 Quite High
Disease Link Frequency Relevance Heat
Disease 55 92.84 High High
Nociception 1 69.68 Quite High
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 4 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of SP 1-11 or SP 6-11 analogues substituted with fluorine in positions 7 and/or 8 maintained the antagonistic effect of SP 1-11 I or SP 6-11 I, though the others were weaker.
Positive_regulation (effect) of SP 1-11 I associated with substance p
1) Confidence 0.40 Published 1987 Journal Neuropeptides Section Abstract Doc Link 2439938 Disease Relevance 0.07 Pain Relevance 1.27
In MOR-expressing cell lines SH-SY5Y, P19, and PC12, B6 MOR promoter possessed high transcription activity than the CXBK promoter, and Sp1 inhibitor PDTC reduced the promoter activities.
Positive_regulation (possessed) of Sp1 in P19 associated with opioid receptor
2) Confidence 0.20 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.63
In MOR-expressing cell lines SH-SY5Y, P19, and PC12, B6 MOR promoter possessed high transcription activity than the CXBK promoter, and Sp1 inhibitor PDTC reduced the promoter activities.
Positive_regulation (possessed) of Sp1 in SH-SY5Y associated with opioid receptor
3) Confidence 0.07 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.63
Somatic instability of trinucleotide repeats not only requires trans-acting factors, but has also been shown to depend on cis-acting sequences [10].
Positive_regulation (requires) of trans-acting
4) Confidence 0.07 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0.44 Pain Relevance 0.04

General Comments

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