INT239993

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh5) plasma membrane (Cdh5)
Anatomy Link Frequency
endothelial cell 4
dendritic cells 2
Cdh5 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 88.88 High High
cytokine 23 46.00 Quite Low
Inflammation 3 31.04 Quite Low
tolerance 2 18.56 Low Low
antagonist 12 9.60 Low Low
palliative 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 2 100.00 Very High Very High Very High
Adhesions 6 97.34 Very High Very High Very High
Dengue 64 83.76 Quite High
Viral Infection 5 58.28 Quite High
INFLAMMATION 4 31.04 Quite Low
Dengue Hemorrhagic Fever 31 5.00 Very Low Very Low Very Low
Infection 22 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas Flk-1 expression is not endothelium-restricted [14], this result, together with the reduced vascular endothelial-cadherin (VE-Cad) expression at days 6 and 8 (Figure 5F), suggests that dorsomorphin treatment decreases endothelial cell differentiation.
Negative_regulation (reduced) of Gene_expression (expression) of VE-Cad in endothelial cell associated with coronary artery disease
1) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0.10 Pain Relevance 0
Whereas Flk-1 expression is not endothelium-restricted [14], this result, together with the reduced vascular endothelial-cadherin (VE-Cad) expression at days 6 and 8 (Figure 5F), suggests that dorsomorphin treatment decreases endothelial cell differentiation.
Negative_regulation (reduced) of Gene_expression (expression) of vascular endothelial-cadherin in endothelial cell associated with coronary artery disease
2) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0.10 Pain Relevance 0
As a result cell-cell adhesion in cells co-cultured with infected dendritic cells was reduced, there were changes in cell morphology and actin cytoskeleton, and a decrease in PECAM 1 VE-cadherin expression[21].
Negative_regulation (decrease) of Gene_expression (expression) of VE-cadherin in dendritic cells associated with adhesions
3) Confidence 0.06 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.56 Pain Relevance 0.04

General Comments

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