INT24000

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Context Info
Confidence 0.22
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.25
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 21 100.00 Very High Very High Very High
intrathecal 1 96.32 Very High Very High Very High
Antinociceptive 2 90.00 High High
tail-flick 1 86.56 High High
antagonist 2 78.40 Quite High
antinociception 1 77.84 Quite High
Spinal cord 1 63.12 Quite High
Analgesic 1 25.00 Low Low
Pain 1 25.00 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 116 98.08 Very High Very High Very High
Obesity 100 82.04 Quite High
Nociception 1 69.68 Quite High
Body Weight 40 31.00 Quite Low
Diabetes Mellitus 12 18.64 Low Low
Aging 2 17.04 Low Low
Peripheral Arterial Disease 26 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 14 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of SP 1-11 or SP 6-11 analogues substituted with fluorine in positions 7 and/or 8 maintained the antagonistic effect of SP 1-11 I or SP 6-11 I, though the others were weaker.
Regulation (effect) of SP 1-11 I associated with substance p
1) Confidence 0.22 Published 1987 Journal Neuropeptides Section Abstract Doc Link 2439938 Disease Relevance 0.07 Pain Relevance 1.27
The use of the F2 can cancel out the possible effects of trans-acting genes on the unwanted donor regions because their alleles are segregating regardless of diplotype for the subcongenic region of the F2.
Spec (possible) Regulation (effects) of trans-acting
2) Confidence 0.05 Published 2010 Journal BMC Genet Section Body Doc Link PMC2955677 Disease Relevance 0.56 Pain Relevance 0
However, trans-acting genes within the region and environmental factors may affect the gene expression levels obtained.
Spec (may) Regulation (affect) of trans-acting
3) Confidence 0.05 Published 2010 Journal BMC Genet Section Body Doc Link PMC2955677 Disease Relevance 0.63 Pain Relevance 0

General Comments

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