INT240031

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 20
Disease Relevance 13.17
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
hepatocytes 6
endothelial cells 4
skeletal muscle 4
blood 2
adipocytes 2
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 171 98.84 Very High Very High Very High
Inflammation 238 95.60 Very High Very High Very High
Inflammatory response 5 77.36 Quite High
rheumatoid arthritis 5 29.68 Quite Low
antagonist 10 27.76 Quite Low
metalloproteinase 4 18.32 Low Low
spinal inflammation 12 16.32 Low Low
tolerance 32 5.00 Very Low Very Low Very Low
alcohol 20 5.00 Very Low Very Low Very Low
Kinase C 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 318 99.92 Very High Very High Very High
Metabolic Syndrome 619 99.70 Very High Very High Very High
Obesity 116 99.34 Very High Very High Very High
Diabetes Mellitus 508 98.00 Very High Very High Very High
Apoptosis 198 96.76 Very High Very High Very High
INFLAMMATION 275 95.60 Very High Very High Very High
Necrosis 28 94.00 High High
Cancer 60 93.64 High High
Overnutrition 106 91.28 High High
Disease 99 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, both overfeeding diets induced significant increases in phosphorylation of mTOR and S6K1, yet only HF overfeeding was associated with increased serine phosphorylation of IRS-1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1
1) Confidence 0.46 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.17 Pain Relevance 0
The main cellular molecular mechanism of insulin desensitization, with consequent insulin resistance presents in MetS-patients, involves increased serine phosphorylation and decreased tyrosine phosphorylation of IRS-1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 associated with metabolic syndrome and insulin resistance
2) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.73 Pain Relevance 0
Phosphorylation of the tyrosine residues 608 on IRS-1 after insulin stimulation is necessary for propagation of the signal with consequent active-mTOR expression.
Positive_regulation (necessary) of Phosphorylation (Phosphorylation) of IRS-1
3) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.71 Pain Relevance 0.06
The main cellular molecular mechanism of insulin desensitization, with consequent insulin resistance presents in MetS-patients, involves increased serine phosphorylation and decreased tyrosine phosphorylation of IRS-1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 associated with metabolic syndrome and insulin resistance
4) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.73 Pain Relevance 0
Indeed, cytokines such as TNF alpha - which are high in MetS-patient blood cause serine phosphorylation of IRS-1 and inhibit its tyrosine phosphorylation with consequent impairment of mTOR function [16].
Positive_regulation (cause) of Phosphorylation (phosphorylation) of IRS-1 in blood associated with metabolic syndrome and cytokine
5) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.80 Pain Relevance 0.18
receptor sub-units and tyrosine phosphorylation of IRS-1 after their recruitment to the cell membrane.
Positive_regulation (after) of Phosphorylation (phosphorylation) of IRS-1
6) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.54 Pain Relevance 0.03
Activation of mTOR and S6K1 kinase leads to serine phosphorylation of IRS-1, with a subsequent decline in tyrosine phosphorylation of IRS-1 and IRS-1-associated PI 3-kinase activity, as discussed above.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of IRS-1
7) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.24 Pain Relevance 0
In contrast, HF overfeeding resulted in increased serine phosphorylation of IRS-1 (Figure 1B) with no change in the amount of total IRS-1 (Figure 2).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1
8) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.06 Pain Relevance 0.03
In contrast, HF overfeeding resulted in increased serine phosphorylation of IRS-1 (Figure 1B) with no change in the amount of total IRS-1 (Figure 2).
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of IRS-1
9) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.06 Pain Relevance 0.03
Assessment of skeletal muscle insulin signaling demonstrated increased tyrosine phosphorylation of IRS-1 (p < 0.001) and increased IRS-1-associated phosphatidylinositol 3 (PI 3)-kinase activity (p < 0.001) following HC overfeeding.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle
10) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2761378 Disease Relevance 0.31 Pain Relevance 0
In contrast, HF overfeeding increased skeletal muscle serine phosophorylation of IRS-1 (p < 0.001) and increased total expression of p85?
Positive_regulation (increased) of Phosphorylation (phosophorylation) of IRS-1 in skeletal muscle
11) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2761378 Disease Relevance 0.23 Pain Relevance 0
Five days of HC overfeeding resulted in significant increases in tyrosine phosphorylation of IRS-1 (Figure 1A), with no change in total IRS-1 protein expression compared to EC feeding (Figure 2).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of IRS-1
12) Confidence 0.27 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.07 Pain Relevance 0.03
Angiotensin also activates JNK and MAPK pathways in endothelial cells, which leads to increased serine phosphorylation of IRS-1, impaired PI-3 kinase activity and finally endothelial dysfunction and probably apoptosis.
Spec (probably) Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 in endothelial cells associated with apoptosis
13) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.09 Pain Relevance 0.03
Angiotensin also activates JNK and MAPK pathways in endothelial cells, which leads to increased serine phosphorylation of IRS-1, impaired PI-3 kinase activity and finally endothelial dysfunction and probably apoptosis.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of IRS-1 in endothelial cells associated with apoptosis
14) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.09 Pain Relevance 0.03
induces insulin resistance through increased serine phosphorylationof insulin receptor substrate-1 (IRS-1), which subsequently converts
Positive_regulation (increased) of Phosphorylation (phosphorylationof) of IRS-1 associated with insulin resistance
15) Confidence 0.12 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2615833 Disease Relevance 1.00 Pain Relevance 0
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of IRS-1 in hepatocytes associated with obesity
16) Confidence 0.08 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.05 Pain Relevance 0.18
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of IRS-1 in hepatocytes associated with obesity
17) Confidence 0.08 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.01 Pain Relevance 0.21
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Positive_regulation (dependent) of in adipocytes Phosphorylation (phosphorylation) of IRS-1 in hepatocytes associated with obesity
18) Confidence 0.03 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.01 Pain Relevance 0.21
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Positive_regulation (increase) of in adipocytes Phosphorylation (phosphorylation) of IRS-1 in hepatocytes associated with obesity
19) Confidence 0.03 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.05 Pain Relevance 0.18
can induce insulin resistance and suppression of Glut4 expression by inhibiting insulin receptor autophosphorylation [11] or by inducing serine phosphorylation of IRS-1 [12].
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of IRS-1 associated with insulin resistance
20) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483433 Disease Relevance 1.12 Pain Relevance 0.32

General Comments

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