INT240034

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Context Info
Confidence 0.79
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GRB2) endosome (GRB2) anatomical structure formation involved in morphogenesis (GRB2)
aging (GRB2) Golgi apparatus (GRB2) protein complex (GRB2)
GRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 99 98.28 Very High Very High Very High
Inflammatory response 2 85.52 High High
Inflammation 40 57.52 Quite High
cytokine 12 56.48 Quite High
antagonist 9 5.00 Very Low Very Low Very Low
spinal inflammation 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 85 98.80 Very High Very High Very High
Adenocarcinoma 6 88.24 High High
Cancer 159 87.36 High High
INFLAMMATION 45 85.52 High High
Metabolic Syndrome 114 80.56 Quite High
Diabetes Mellitus 26 79.68 Quite High
Stomach Cancer 9 79.12 Quite High
Insulin Resistance 36 77.84 Quite High
Pituitary Cancer 2 62.60 Quite High
Syndrome 12 59.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the MAP kinase pathway begins with phosphorylation of Shc, Grb2/Sos and ras and results in the activation of extracellular signal-regulated kinase (ERK)-1 and ERK-2.
Phosphorylation (phosphorylation) of Grb2
1) Confidence 0.79 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483433 Disease Relevance 0.94 Pain Relevance 0.15
Recent study clearly confirmed that almost one dozen of factors such as SHP-1, Grd2, Grb2, phosphatidylinositol 3-OH kinase (PI3K), have also binding abilities to CagA phosphorylation sites [34].
Phosphorylation (phosphorylation) of Grb2
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.28 Pain Relevance 0
In the ovarian cancer cell line SKOV-3, CXCL8/IL-8 was shown to induce transient phosphorylation of EGFR and its association with the adaptor molecules Shc and Grb2, suggests an important cross-talk between chemokine and growth factor pathways [39].
Phosphorylation (phosphorylation) of Grb2 associated with chemokine and ovarian cancer
3) Confidence 0.12 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.58 Pain Relevance 0.10

General Comments

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