INT240041

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.80
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apob) transport (Apob) extracellular space (Apob)
extracellular region (Apob) endoplasmic reticulum (Apob) enzyme binding (Apob)
Anatomy Link Frequency
liver 2
Apob (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 30 71.84 Quite High
cytokine 9 70.80 Quite High
rheumatoid arthritis 3 45.40 Quite Low
spinal inflammation 8 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
spondylitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5 100.00 Very High Very High Very High
Hyperglycemia 3 99.94 Very High Very High Very High
Insulin Resistance 36 98.08 Very High Very High Very High
Obesity 7 86.24 High High
Metabolic Syndrome 114 84.08 Quite High
Congenital Anomalies 2 77.52 Quite High
INFLAMMATION 32 71.84 Quite High
Dyslipidemia /

Combined Dyslipidemia

3 71.84 Quite High
Hypertension 5 70.68 Quite High
Hyperinsulinism 2 53.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The non-esterified fatty acids (NEFAs) produced in excess flux to the liver where they may impair liver metabolism (liver insulin resistance); more specifically, they increase hepatic glucose production (contributing to hyperglycemia), decrease apolipoprotein B degradation, and increase triacylglycerolrich lipoproteins [20].
Negative_regulation (decrease) of Protein_catabolism (degradation) of apolipoprotein B in liver associated with hyperglycemia, insulin resistance and disorder of lipid metabolism
1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483433 Disease Relevance 1.73 Pain Relevance 0.13

General Comments

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