INT240052

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F9) extracellular region (F9) plasma membrane (F9)
Anatomy Link Frequency
muscle 4
F9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 22 50.00 Quite Low
rheumatoid arthritis 15 39.68 Quite Low
Osteoarthritis 5 8.32 Low Low
Etanercept 20 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Adalimumab 6 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 3 99.60 Very High Very High Very High
Factor Ix Deficiency 2 96.64 Very High Very High Very High
Disease 27 87.04 High High
Infection 5 82.32 Quite High
Toxicity 2 77.64 Quite High
Cancer 6 72.72 Quite High
Reprotox - General 1 1 60.40 Quite High
Cardiomyopathy 26 59.44 Quite High
Muscle Disease 8 52.72 Quite High
Muscular Dystrophy 26 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hemophilia B dogs, factor IX (FIX) was recovered >4 years following AAV2-FIX injection in both muscle biopsies and circulation.
Negative_regulation (recovered) of Gene_expression (injection) of FIX in muscle associated with coagulation disorder
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.39 Pain Relevance 0
In hemophilia B dogs, factor IX (FIX) was recovered >4 years following AAV2-FIX injection in both muscle biopsies and circulation.
Negative_regulation (recovered) of Gene_expression (injection) of FIX in muscle associated with coagulation disorder
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.39 Pain Relevance 0
This led to transient transaminitis and loss of factor IX expression [27].
Negative_regulation (loss) of Gene_expression (expression) of factor IX
3) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483436 Disease Relevance 0.55 Pain Relevance 0

General Comments

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