INT240057

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.11
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOB, NME8) endosome (RHOB) intracellular (RHOB)
GTPase activity (RHOB) cytoplasm (NME8) cytosol (RHOB)
Anatomy Link Frequency
knee 4
RHOB (Homo sapiens)
NME8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 165 99.56 Very High Very High Very High
Arthritis 20 85.12 High High
Pain 10 16.64 Low Low
Inflammation 5 9.44 Low Low
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 155 99.56 Very High Very High Very High
Disease 10 98.20 Very High Very High Very High
Arthritis 15 85.12 High High
Death 5 84.44 Quite High
Apoptosis 5 84.00 Quite High
Osteoarthritis 10 77.04 Quite High
Arthropathy 10 74.40 Quite High
Pain 10 16.64 Low Low
INFLAMMATION 5 9.44 Low Low
Infectious Arthritis 5 6.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the replication of association between the RHOB and TXNDC3 SNPs and knee OA susceptibility, we conducted two case-control studies in Han Chinese and Japanese populations and a meta-analysis.


RHOB Spec (examine) Binding (association) of TXNDC3 in knee associated with osteoarthritis
1) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.87 Pain Relevance 0.27
To examine the replication of association between the RHOB and TXNDC3 SNPs and knee OA susceptibility, we conducted two case-control studies in Han Chinese and Japanese populations and a meta-analysis.


RHOB Spec (examine) Binding (association) of TXNDC3 in knee associated with osteoarthritis
2) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.87 Pain Relevance 0.27
Conflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians.
RHOB Binding (association) of TXNDC3 in knee associated with knee osteoarthritis and osteoarthritis
3) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483443 Disease Relevance 0.43 Pain Relevance 0.21
However, a replication study in the UK found no association of RHOB and TXNDC3 with knee OA, even though the ethnicity and disease ascertainment were basically the same in the two studies [10].
RHOB Neg (no) Binding (association) of TXNDC3 in knee associated with disease and osteoarthritis
4) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 1.00 Pain Relevance 0.34
Marh and coworkers [7] examined regulatory polymorphisms in the 5' regions of the genes that potentially allow for differential expression in vivo, and they found positive association for RHOB and TXNDC3 in European Caucasians living in Germany.
RHOB Binding (association) of TXNDC3
5) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.95 Pain Relevance 0.40

General Comments

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