INT240058

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.29
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOB) endosome (RHOB) intracellular (RHOB)
GTPase activity (RHOB) cytosol (RHOB) cell adhesion (RHOB)
Anatomy Link Frequency
articular 1
RHOB (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 225 99.84 Very High Very High Very High
rheumatoid arthritis 9 96.72 Very High Very High Very High
Arthritis 13 82.16 Quite High
Inflammatory response 3 80.32 Quite High
chemokine 3 34.00 Quite Low
Inflammation 28 5.00 Very Low Very Low Very Low
COX-2 inhibitor 9 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 215 99.84 Very High Very High Very High
Rheumatoid Arthritis 9 96.72 Very High Very High Very High
Knee Osteoarthritis 31 96.44 Very High Very High Very High
Apoptosis 34 82.88 Quite High
Arthritis 12 82.16 Quite High
Death 22 81.68 Quite High
INFLAMMATION 34 79.96 Quite High
Adhesions 6 75.52 Quite High
Disease 14 44.16 Quite Low
Arthropathy 5 7.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, our data are consistent with prior observations suggesting that RHOB, a member of the Rho GTP-binding protein, is overexpressed in OA [17], [18] and the positive association in the expression levels of RHOB and PARP-1 [19].
Gene_expression (levels) of RHOB associated with osteoarthritis
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.08 Pain Relevance 0.47
Moreover, our data are consistent with prior observations suggesting that RHOB, a member of the Rho GTP-binding protein, is overexpressed in OA [17], [18] and the positive association in the expression levels of RHOB and PARP-1 [19].
Gene_expression (expression) of RHOB associated with osteoarthritis
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.08 Pain Relevance 0.47
Moreover, our data are consistent with prior observations suggesting that RHOB, a member of the Rho GTP-binding protein, is overexpressed in OA [17], [18] and the positive association in the expression levels of RHOB and PARP-1 [19].
Gene_expression (overexpressed) of RHOB associated with osteoarthritis
3) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.10 Pain Relevance 0.47
RHOB belongs to the family of small GTPases, and is constitutively expressed and essential in adult articular chondrocytes, but it is significantly downregulated in OA chondrocytes [7].
Gene_expression (expressed) of RHOB in articular associated with osteoarthritis
4) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 1.02 Pain Relevance 0.43

General Comments

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