INT240060

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.85
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NME8) cytoplasm (NME8)
Anatomy Link Frequency
knee 5
NME8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 231 99.56 Very High Very High Very High
Arthritis 28 85.12 High High
Pain 14 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 217 99.56 Very High Very High Very High
Disease 14 98.20 Very High Very High Very High
Osteoarthritis 14 93.76 High High
Arthritis 21 85.12 High High
Death 7 84.44 Quite High
Apoptosis 7 84.00 Quite High
Arthropathy 14 59.60 Quite High
Obesity 28 11.40 Low Low
Pain 14 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of TXNDC3 with knee OA was replicated in East Asian individuals, whereas a lack of association for RHOB was identified.
TXNDC3 Binding (association) of in knee associated with osteoarthritis
1) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.31 Pain Relevance 0.15
There was a significant association for TXNDC3 in East Asian populations with nonsignificant heterogeneity (P = 0.03 for CC versus CT+TT; P = 0.02 for C allele versus T allele; Table 5).


TXNDC3 Binding (association) of
2) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.07 Pain Relevance 0.04
However, a replication study in the UK found no association of RHOB and TXNDC3 with knee OA, even though the ethnicity and disease ascertainment were basically the same in the two studies [10].
TXNDC3 Neg (no) Binding (association) of in knee associated with disease and osteoarthritis
3) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 1.00 Pain Relevance 0.34
Our study replicates the association, previously reported in European Caucasians, of TXNDC3 with knee OA susceptibility in an East Asian population.


TXNDC3 Binding (association) of in knee associated with osteoarthritis
4) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.73 Pain Relevance 0.36
Our study replicates the association, previously reported in European Caucasians, of TXNDC3 with knee OA susceptibility in an East Asian population.



TXNDC3 Binding (association) of in knee associated with osteoarthritis
5) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483443 Disease Relevance 0.37 Pain Relevance 0.18
Conflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians.
TXNDC3 Binding (association) of in knee associated with knee osteoarthritis and osteoarthritis
6) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483443 Disease Relevance 0.43 Pain Relevance 0.21
Marh and coworkers [7] examined regulatory polymorphisms in the 5' regions of the genes that potentially allow for differential expression in vivo, and they found positive association for RHOB and TXNDC3 in European Caucasians living in Germany.
TXNDC3 Binding (association) of
7) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.95 Pain Relevance 0.40

General Comments

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