INT240064

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.29
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DAK) lyase activity (DAK)
Anatomy Link Frequency
neuronal 1
retina 1
leukocytes 1
erythrocytes 1
DAK (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 1 98.96 Very High Very High Very High
antidepressant 26 98.94 Very High Very High Very High
agonist 2 93.40 High High
depression 146 81.12 Quite High
fluoxetine 6 77.44 Quite High
rheumatoid arthritis 16 31.88 Quite Low
cytokine 20 20.76 Low Low
Inflammation 52 20.40 Low Low
Dopamine 16 8.48 Low Low
Serotonin 30 7.96 Low Low
Disease Link Frequency Relevance Heat
Post-partum Depression 60 82.00 Quite High
Depression 116 80.32 Quite High
Weight Gain 9 50.00 Quite Low
Premature Birth 5 39.84 Quite Low
Rheumatoid Arthritis 16 31.88 Quite Low
Adhesions 2 23.48 Low Low
INFLAMMATION 62 20.40 Low Low
Lifespan 2 15.04 Low Low
Viral Infection 4 5.04 Very Low Very Low Very Low
Obesity 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deposition of DHA in the retina and in the cerebral cortex occur especially during the third trimester of gestation and in the first six months of extrauterine life; therefore, both the last three months of gestation and first few months after birth are particularly vulnerable to developmental deficits, if DHA is limiting [10,14].
Regulation (deposition) of DHA in retina associated with cerebral cortex
1) Confidence 0.06 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2707376 Disease Relevance 0 Pain Relevance 0.05
Thus, changes in the relative abundance of specific LC-PUFAs, particularly DHA, can affect neuronal function through a variety of mechanisms.
Regulation (changes) of DHA in neuronal
2) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0 Pain Relevance 0.05
Despite the negative results of some trials, subsequent meta-analyses and other post hoc evaluations generally support the antidepressant efficacy of n-3 PUFAs, particularly EPA, though the efficacy of DHA remains unclear [110–114].
Regulation (efficacy) of DHA associated with antidepressant
3) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.29 Pain Relevance 0.47
Thus changes in levels of EPA and DHA in erythrocytes and leukocytes appear to correlate during n-3 LCPUFA supplementation [34,35], although the rate of incorporation between these cell types is different in the first 6 to 12 weeks of supplementation.
Regulation (changes) of DHA in leukocytes
4) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0
Thus changes in levels of EPA and DHA in erythrocytes and leukocytes appear to correlate during n-3 LCPUFA supplementation [34,35], although the rate of incorporation between these cell types is different in the first 6 to 12 weeks of supplementation.
Regulation (changes) of DHA in erythrocytes
5) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0

General Comments

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