INT240080

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.34
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 115 99.92 Very High Very High Very High
Osteoarthritis 140 99.84 Very High Very High Very High
Lasting pain 60 99.16 Very High Very High Very High
Pain score 5 92.44 High High
Dynorphin 50 80.00 Quite High
Pain management 15 75.00 Quite High
opiate 5 72.16 Quite High
Hyperalgesia 5 68.40 Quite High
Spinal cord 20 67.84 Quite High
Opioid 20 65.28 Quite High
Disease Link Frequency Relevance Heat
Pain 190 99.92 Very High Very High Very High
Frailty 145 99.84 Very High Very High Very High
Arthritis 25 75.00 Quite High
Repression 25 73.84 Quite High
Hyperalgesia 5 68.40 Quite High
Targeted Disruption 10 64.80 Quite High
INFLAMMATION 5 58.40 Quite High
Injury 10 57.60 Quite High
Nociception 15 56.68 Quite High
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DREAM mRNA expression is reduced in osteoarthritis patients with high visual analog scale score
Negative_regulation (reduced) of Transcription (expression) of DREAM associated with osteoarthritis
1) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.72 Pain Relevance 0.43
OA patients with a pain intensity of less than or equal to 40 on the VAS (n = 9) displayed no significant reduction in the expression of DREAM mRNA compared with the healthy control group (ANOVA: F (2,43) = 7.91; P < 0.001) (Figure 2).
Neg (no) Negative_regulation (reduction) of Transcription (expression) of DREAM associated with pain and osteoarthritis
2) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.97 Pain Relevance 0.68
The level of DREAM mRNA expression was still reduced to 40.76% ± 6.74% of baseline expression at 72 hours after transfection (Figure 3b).


Negative_regulation (reduced) of Transcription (expression) of DREAM
3) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.25 Pain Relevance 0.22
In addition, DREAM mRNA expression was significantly reduced in OA patients with chronic pain (pain intensity as measured by a visual analog scale scale of greater than 40), but no pdyn expression was detectable.


Negative_regulation (reduced) of Transcription (expression) of DREAM associated with pain, lasting pain and osteoarthritis
4) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 1.22 Pain Relevance 0.93
Reduced DREAM mRNA expression appears not to be sufficient to relieve pain and/or counteract other mechanisms induced by chronic pain, which possibly include dramatic changes in the transcriptome in conditions of chronic pain.
Negative_regulation (Reduced) of Transcription (expression) of DREAM associated with pain and lasting pain
5) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.18 Pain Relevance 1.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox