INT240092

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.58
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KCNIP3) signal transduction (KCNIP3) Golgi apparatus (KCNIP3)
endoplasmic reticulum (KCNIP3) plasma membrane (KCNIP3) nucleus (KCNIP3)
Anatomy Link Frequency
fibroblast 2
KCNIP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 138 99.78 Very High Very High Very High
Osteoarthritis 168 99.52 Very High Very High Very High
Lasting pain 72 98.84 Very High Very High Very High
Dynorphin 60 98.08 Very High Very High Very High
Kappa opioid receptor 48 97.28 Very High Very High Very High
Opioid 24 89.24 High High
potassium channel 6 88.68 High High
Inflammation 6 88.56 High High
Spinal cord 24 88.40 High High
Pain management 18 88.40 High High
Disease Link Frequency Relevance Heat
Pain 228 99.78 Very High Very High Very High
Frailty 174 99.52 Very High Very High Very High
Alzheimer's Dementia 6 91.92 High High
INFLAMMATION 6 88.56 High High
Injury 12 87.76 High High
Repression 30 76.84 Quite High
Arthritis 30 75.00 Quite High
Hyperalgesia 6 63.60 Quite High
Nociception 18 62.36 Quite High
Targeted Disruption 12 60.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The targeted inhibition of the expression of DREAM in SFLCs might enhance the endogenous level of dynorphin acting on KOR, using siRNAs locally in the periphery.
Negative_regulation (inhibition) of Gene_expression (expression) of DREAM associated with dynorphin and kappa opioid receptor
1) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.90 Pain Relevance 0.64
(b) Does targeted inhibition of DREAM expression in synovial fibroblast-like cells (SFLCs) enhance the endogenous level of dynophin action on KOR in the periphery?
Negative_regulation (inhibition) of Gene_expression (expression) of DREAM in fibroblast associated with kappa opioid receptor
2) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.72 Pain Relevance 0.58
Inhibiting DREAM expression using small interfering RNAs
Negative_regulation (Inhibiting) of Gene_expression (expression) of DREAM
3) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.88 Pain Relevance 0.66
In addition, contradicting the theory of DREAM action on pain relief, a reduction of the expression level of DREAM was shown in PBMCs from OA patients with a VAS score of greater than 40 (Figure 2).
Negative_regulation (reduction) of Gene_expression (expression) of DREAM associated with pain and osteoarthritis
4) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.70 Pain Relevance 0.85
In addition, in the in vivo situation, a reduction of DREAM expression coincides with enhanced pain.
Negative_regulation (reduction) of Gene_expression (expression) of DREAM associated with pain
5) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.14 Pain Relevance 1.29
Inhibiting transcription using siRNAs led to a marked reduction in DREAM expression after 24, 48, and 72 hours.
Negative_regulation (reduction) of Gene_expression (expression) of DREAM
6) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 1.22 Pain Relevance 0.94

General Comments

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