INT240095

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PDYN, Oprk1) signal transduction (Oprk1) cell death (PDYN)
extracellular region (PDYN) signal transducer activity (Oprk1)
PDYN (Homo sapiens)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 10 100.00 Very High Very High Very High
Kappa opioid receptor 8 100.00 Very High Very High Very High
Pain 23 98.60 Very High Very High Very High
antagonist 3 90.68 High High
Neuropathic pain 1 85.08 High High
Spinal cord 4 73.36 Quite High
Lasting pain 12 72.92 Quite High
Pain management 3 50.00 Quite Low
Osteoarthritis 28 41.32 Quite Low
potassium channel 1 11.76 Low Low
Disease Link Frequency Relevance Heat
Pain 38 98.60 Very High Very High Very High
Nociception 3 92.64 High High
Neuropathic Pain 1 85.08 High High
Repression 5 80.48 Quite High
Disease 1 74.92 Quite High
Arthritis 5 74.56 Quite High
Frailty 29 41.32 Quite Low
Alzheimer's Dementia 1 5.20 Low Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynorphin interacts preferably with the kappa opioid receptor (KOR), which is part of the endogenous pain-relieving machinery [10].
Dynorphin Binding (interacts) of KOR associated with pain, dynorphin and kappa opioid receptor
1) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.30 Pain Relevance 1.22

General Comments

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