INT24011

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 3.03
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
spinal 1
midbrain 1
Drd3 (Rattus norvegicus)
Drd3 - S9G (1)
Pain Link Frequency Relevance Heat
Dopamine 218 100.00 Very High Very High Very High
agonist 32 99.96 Very High Very High Very High
antagonist 26 99.96 Very High Very High Very High
Opioid 2 99.76 Very High Very High Very High
Morphine 8 99.58 Very High Very High Very High
addiction 4 99.48 Very High Very High Very High
midbrain 3 97.90 Very High Very High Very High
depression 17 97.56 Very High Very High Very High
withdrawal 2 96.80 Very High Very High Very High
Substantia nigra 10 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Amnesia 5 99.90 Very High Very High Very High
Anxiety Disorder 420 99.80 Very High Very High Very High
Opiate Addiction 1 99.76 Very High Very High Very High
Depression 21 97.56 Very High Very High Very High
Alcohol Addiction 1 92.92 High High
Manic Depressive Disorder 125 92.24 High High
Psychosis 4 75.92 Quite High
Drug Dependence 3 75.00 Quite High
Tics 8 72.24 Quite High
Targeted Disruption 2 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Behavioural sensitization, induction of D3 receptor binding and changes in prodynorphin/preprotachykinin ratio were all prevented together when levodopa was continuously delivered or intermittently delivered in combination with R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1H-3-benzazepine (SCH 23390), a selective D1 receptor antagonist.
D3 receptor Binding (binding) of associated with antagonist
1) Confidence 0.47 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886351 Disease Relevance 0 Pain Relevance 0.23
The simple tetrahydroisoquinolines (3,4-dihydroxytetrahydroisoquinoline and salsolinol), the four isomeric mono-O-methyl derivatives of 2,3,10,11-tetrahydroxyberbine and tetrahydropapaveroline were the most potent inhibitors of 3H-apomorphine binding to dopaminergic receptor agonist sites.
dopaminergic receptor Binding (binding) of associated with agonist
2) Confidence 0.45 Published 1983 Journal J. Neurosci. Res. Section Abstract Doc Link 6313954 Disease Relevance 0 Pain Relevance 0.32
The tetrahydroprotoberberines, as a class, were the most potent inhibitors of 3H-spiroperidol binding to dopaminergic receptor antagonist sites and of 3H-WB-4101 binding to alpha 1-adrenergic receptors.
dopaminergic receptor Binding (binding) of associated with antagonist
3) Confidence 0.45 Published 1983 Journal J. Neurosci. Res. Section Abstract Doc Link 6313954 Disease Relevance 0 Pain Relevance 0.31
The effect of apomorphine in spinal rats was counteracted by dopaminergic receptor antagonists (cis-flupenthixol and (+)-butaclamol), but not by their stereoisomers.
dopaminergic receptor Binding (counteracted) of in spinal associated with antagonist
4) Confidence 0.37 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6856048 Disease Relevance 0 Pain Relevance 0.44
Changes in D3 receptor binding and behavioural sensitization during intermittent administration of levodopa paralleled changes in prodynorphin/preprotachykinin rather than preproenkephalin/prodynorphin and preproenkephalin/preprotachykinin mRNA ratios.
D3 receptor Binding (binding) of
5) Confidence 0.37 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886351 Disease Relevance 0 Pain Relevance 0.20
This descriptive study identified none of these three peptides as a single and specific target for dopaminergic receptor blockade.
dopaminergic receptor Binding (target) of
6) Confidence 0.34 Published 1986 Journal Neuropsychobiology Section Abstract Doc Link 2441312 Disease Relevance 0 Pain Relevance 0.27
Generally, the decreased levels of midbrain DA and DOPAC detectable in aged rats have little correlation with age-related changes in the density of dopaminergic receptor binding or the density of DA uptake sites [37].
dopaminergic receptor Binding (binding) of in midbrain associated with dopamine and midbrain
7) Confidence 0.12 Published 2001 Journal BMC Physiol Section Body Doc Link PMC61031 Disease Relevance 0 Pain Relevance 0.47
Aiming to evaluate common genetic variation for association with clinical improvement in BDI depression following treatment with OFC, Perlis et al. [200] analyzed a cohort of 88 patients treated with OFC, showing significant association for dopamine D3 receptor (DRD3) and HRH1 genes and response to OFC.
DRD3 Spec (analyzed) Binding (association) of associated with dopamine and depression
8) Confidence 0.11 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.53 Pain Relevance 0.21
To date, there have been only three studies concerning the associations between the DRD3 gene and OCD.
DRD3 gene Binding (associations) of associated with anxiety disorder
9) Confidence 0.10 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.98 Pain Relevance 0.28
All of these studies showed no association between the Ser9Gly variant of DRD3 gene and OCD.51,73,78


DRD3 gene (S9G) Neg (no) Binding (association) of associated with anxiety disorder
10) Confidence 0.10 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.90 Pain Relevance 0.34
In addition, other dopaminergic receptor gene polymorphisms have also associated with opioid dependence.
dopaminergic receptor gene Binding (associated) of associated with addiction and opioid
11) Confidence 0.04 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15288384 Disease Relevance 0.27 Pain Relevance 0.75
D3-receptor binding (but not mRNA) was also demonstrated in the monkey GPi (Quik et al., 2000), and D2- and D3-receptor mRNA and binding sites have been identified in the human GPi (Gurevich and Joyce, 1999).
D3-receptor Binding (binding) of
12) Confidence 0.04 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.05 Pain Relevance 0.08
Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors.
D2-dopaminergic Binding (binding) of
13) Confidence 0.02 Published 1983 Journal Jpn. J. Pharmacol. Section Title Doc Link 6138453 Disease Relevance 0 Pain Relevance 0.17
Influence of nitric oxide on morphine-induced amnesia and interactions with dopaminergic receptor agents.
dopaminergic receptor Binding (interactions) of associated with amnesia and morphine
14) Confidence 0.01 Published 2006 Journal Physiol. Behav. Section Title Doc Link 16631214 Disease Relevance 0.30 Pain Relevance 0.57

General Comments

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