INT240125

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 39 79.80 Quite High
Inflammation 24 60.64 Quite High
Onset of action 3 60.12 Quite High
cytokine 7 36.80 Quite Low
anakinra 9 36.00 Quite Low
methotrexate 7 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Rheumatism 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 9 99.32 Very High Very High Very High
Acute Coronary Syndrome 8 92.20 High High
Disease 15 84.16 Quite High
Rheumatoid Arthritis 39 79.80 Quite High
Necrosis 3 64.96 Quite High
Cancer 3 64.60 Quite High
INFLAMMATION 17 60.64 Quite High
Diabetes Mellitus 12 56.64 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 54.68 Quite High
Dyslipidemia /

Combined Dyslipidemia

16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, CRP reduction was found to be necessary for achievment of clinical response, as expected, but it was not sufficient to explain or even predict clinical response, because CRP reduction was also observed in the absence of clinical response.
Positive_regulation (necessary) of Negative_regulation (reduction) of CRP
1) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 0.32 Pain Relevance 0.10
In addition, administration of pitavastatin has been reported to induce a decrease in the serum level of high-sensitivity CRP associated with atherosclerosis, and increase in the serum level of adiponectin.67,73 The short-and intermediate-term effects of pitavastatin and atorvastatin on the endothelial functions have been evaluated.
Positive_regulation (induce) of Negative_regulation (decrease) of CRP associated with atherosclerosis
2) Confidence 0.11 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.67 Pain Relevance 0.03

General Comments

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