INT240127

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 22.42
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
Arms 2
head 1
heart 1
aortic valve 1
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 288 100.00 Very High Very High Very High
Inflammation 103 100.00 Very High Very High Very High
cINOD 63 99.54 Very High Very High Very High
COX-2 inhibitor 18 99.32 Very High Very High Very High
methotrexate 9 98.82 Very High Very High Very High
Pain 37 90.84 High High
Angina 81 90.52 High High
Central nervous system 10 86.60 High High
Arthritis 28 84.96 Quite High
Inflammatory marker 9 74.56 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 288 100.00 Very High Very High Very High
INFLAMMATION 121 100.00 Very High Very High Very High
Obesity 255 99.80 Very High Very High Very High
Pulmonary Hypertension 90 99.42 Very High Very High Very High
Myocardial Infarction 665 99.40 Very High Very High Very High
Disease 346 99.40 Very High Very High Very High
Hypertension 51 99.32 Very High Very High Very High
Cardiovascular Disease 234 98.96 Very High Very High Very High
Natriuresis 279 98.64 Very High Very High Very High
Diabetes Mellitus 25 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As well, the interpretation of both BNP and NT-proBNP may be hindered by higher BMI; whether it interferes with the prognostic value of the markers remained unclear.
BNP Binding (interpretation) of
1) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.22 Pain Relevance 0
As well, the interpretation of both BNP and NT-proBNP may be hindered by higher BMI; whether it interferes with the prognostic value of the markers remained unclear.
NT-proBNP Binding (interpretation) of
2) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.22 Pain Relevance 0
Firstly, NT-proBNP is associated with older age, hypertension, renal impairment, diabetes mellitus and pre-existent left ventricular dysfunction, which are also predictors of worse outcome.
NT-proBNP Binding (associated) of associated with left ventricular dysfunction, diabetes mellitus and hypertension
3) Confidence 0.36 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.18 Pain Relevance 0.13
Despite the potential differences and analytical concerns, recent head-to-head comparisons show that BNP correlates as well as NT-proBNP with clinical variables in patients with HF, indicating that most of the results of the BNP and NT-proBNP studies are generally transposable.29–31

NT-proBNP: Diagnostic in Dyspnea

NT-proBNP Binding (as) of in head associated with dyspnea and myocardial infarction
4) Confidence 0.33 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.41 Pain Relevance 0
Although it has proven to induce natriuresis, it remains unclear whether it plays any role in the physiology of mammals.6,13

BNP and NT-proBNP: Brothers in Arms?

BNP Binding (mammals.6,13) of in Arms associated with natriuresis
5) Confidence 0.33 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.39 Pain Relevance 0.04
Although it has proven to induce natriuresis, it remains unclear whether it plays any role in the physiology of mammals.6,13

BNP and NT-proBNP: Brothers in Arms?

NT-proBNP Binding (mammals.6,13) of in Arms associated with natriuresis
6) Confidence 0.33 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.39 Pain Relevance 0.04
Although there is a higher NT-proBNP/BNP ratio described in patients with renal impairment,97 one should bear in mind that BNP is also degraded by neutral endopeptidase 24.11 and the NPR-C receptor, which are both up-regulated in patients with renal impairment.98,99
NT-proBNP Binding (ratio) of
7) Confidence 0.33 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.52 Pain Relevance 0
Although there is a higher NT-proBNP/BNP ratio described in patients with renal impairment,97 one should bear in mind that BNP is also degraded by neutral endopeptidase 24.11 and the NPR-C receptor, which are both up-regulated in patients with renal impairment.98,99
BNP Binding (ratio) of
8) Confidence 0.33 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.51 Pain Relevance 0
Indeed, a small study by Allonore et al. performed in 40 patients with systemic sclerosis suggests that NT-proBNP can be used as a screening tool for the early stage of PAH, when clinical symptoms are not present yet.73

NT-proBNP and Obesity

NT-proBNP Neg (not) Binding (not) of associated with pulmonary hypertension, obesity and systemic sclerosis
9) Confidence 0.33 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.81 Pain Relevance 0.04
As an example, several studies have shown that NT-proBNP indeed correlates not only with onset and severity of symptoms but also with prognosis in aortic stenosis.56–59 Gerber et al. studied 74 patients with isolated aortic stenosis, and found that, after adjustment for age, sex, serum creatinine, aortic valve area and LVEF, that NT-proBNP concentrations were 1.74 times higher (1.12–2.69 95% CI) for symptomatic than asymptomatic patients with aortic stenosis.57 This is supported by the work of Weber and colleagues, who have also shown in their studies that NT-proBNP elevations were the earliest predictor of symptom onset, which is usually the moment when surgery is considered.56,60 Also in mitral valvular disease, several studies have indicated that the severity of valvular disease correlates with NT-proBNP concentrations, not only in mitral regurgitation,61–63 but also in mitral stenosis.63–65
NT-proBNP Binding (example) of in aortic valve associated with mitral valve stenosis, mitral valve insufficiency, cv unclassified under development and disease
10) Confidence 0.33 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.24 Pain Relevance 0
The validity of our model is supported by the association between NT-proBNP levels and self-reported CVD.
NT-proBNP Binding (association) of associated with cardiovascular disease
11) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.08 Pain Relevance 0.24
To our knowledge, no previous study has examined the association between markers of inflammation in RA and BNP/NT-proBNP.
NT-proBNP Spec (examined) Binding (association) of associated with inflammation and rheumatoid arthritis
12) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.84 Pain Relevance 0.38
The presence of hypertension, smoking status, and prevalent use of glucocorticoids, DMARDs (including subgroups of tumor necrosis factor [TNF] inhibitors and methotrexate users), COX-2 inhibitors, or NSAIDs was not significantly associated with NT-proBNP levels (data not shown).
NT-proBNP Binding (associated) of associated with necrosis, nicotine addiction, cancer, hypertension, cinod, cox-2 inhibitor and methotrexate
13) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.00 Pain Relevance 0.26
It could be argued that the association between CRP and NT-proBNP identified in our study is a consequence of the inflammatory nature of ventricular remodelling.
NT-proBNP Binding (association) of associated with inflammation
14) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.82 Pain Relevance 0.39
200 pmol/L; male: < 50 years of age, NT-proBNP ?
NT-proBNP Binding (age) of
15) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.21 Pain Relevance 0.09
However, we did find disease duration to be significantly associated with NT-proBNP levels at the 10-year cross-sectional analysis.
NT-proBNP Binding (associated) of associated with disease
16) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.69 Pain Relevance 0.29
We found no significant association between these measures and NT-proBNP levels in our multivariate longitudinal analyses.
NT-proBNP Neg (no) Binding (association) of
17) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.27 Pain Relevance 0.27
To our knowledge, no previous study has examined the association between markers of inflammation in RA and BNP/NT-proBNP.
BNP Spec (examined) Binding (association) of associated with inflammation and rheumatoid arthritis
18) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.83 Pain Relevance 0.38
The use of DMARDs, NSAIDs, or glucocorticoids was not significantly associated with NT-proBNP levels.
NT-proBNP Binding (associated) of associated with cinod
19) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.68 Pain Relevance 0.16
This method nevertheless shows a better diagnosis ability than recognized laboratory markers such as BNP and NT-proBNP [33] in possible heart failure patients.


BNP Binding (recognized) of in heart associated with myocardial infarction
20) Confidence 0.02 Published 2010 Journal BMC Med Section Body Doc Link PMC2832616 Disease Relevance 1.13 Pain Relevance 0.57

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