INT240131

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 11.53
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp, Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Crp (Mus musculus)
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 256 99.90 Very High Very High Very High
Inflammation 104 98.04 Very High Very High Very High
Inflammatory marker 8 95.84 Very High Very High Very High
cINOD 56 88.96 High High
Arthritis 16 83.28 Quite High
methotrexate 8 55.44 Quite High
COX-2 inhibitor 16 53.76 Quite High
Catecholamine 4 45.12 Quite Low
Angina 16 24.32 Low Low
ischemia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 272 100.00 Very High Very High Very High
Rheumatoid Arthritis 256 99.90 Very High Very High Very High
Obesity 64 99.72 Very High Very High Very High
Cardiovascular Disease 204 98.60 Very High Very High Very High
INFLAMMATION 120 98.04 Very High Very High Very High
Heart Rate Under Development 120 96.80 Very High Very High Very High
Death 84 96.08 Very High Very High Very High
Hypertension 28 96.04 Very High Very High Very High
Sudden Death 8 88.60 High High
Myocardial Infarction 108 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that CRP was significantly associated with levels of NT-proBNP at all time points.
CRP Binding (associated) of NT-proBNP
1) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.11 Pain Relevance 0.27
CRP levels are linearly associated with levels of NT-proBNP in cross-sectional and longitudinal analyses of patients with RA.
CRP Spec (analyses) Binding (associated) of NT-proBNP associated with rheumatoid arthritis
2) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483462 Disease Relevance 0.76 Pain Relevance 0.25
At the 10-year follow-up examination, age, gender, BMI, creatinine, CRP, and disease duration were significantly associated with NT-proBNP levels (Table 3).
CRP Binding (associated) of NT-proBNP associated with obesity and disease
3) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.98 Pain Relevance 0.25
Duration of RA and CRP levels were independently associated with NT-proBNP in the final model that was adjusted for gender, age, and creatinine levels (r2 adjusted = 0.38; P < 0.001).
CRP Binding (associated) of NT-proBNP associated with rheumatoid arthritis
4) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483462 Disease Relevance 1.01 Pain Relevance 0.32
C-reactive protein (CRP) levels at baseline were cross-sectionally associated with NT-proBNP levels after adjustment for age and gender (r2 adjusted = 0.23; P < 0.05).
CRP Binding (associated) of NT-proBNP
5) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483462 Disease Relevance 1.02 Pain Relevance 0.31
CRP levels at baseline were significantly associated with NT-proBNP in the linear regression analyses (Table 2).
CRP Spec (analyses) Binding (associated) of NT-proBNP
6) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 0.53 Pain Relevance 0.16
It could be argued that the association between CRP and NT-proBNP identified in our study is a consequence of the inflammatory nature of ventricular remodelling.
CRP Binding (association) of NT-proBNP associated with inflammation
7) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.82 Pain Relevance 0.39
CRP levels were linearly associated with levels of NT-proBNP in this cross-sectional and longitudinal study of 238 patients with RA.
CRP Binding (associated) of NT-proBNP associated with rheumatoid arthritis
8) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.71 Pain Relevance 0.16
In addition, both NT-proBNP and CRP were significantly associated not only with all clinical events but also with all subsidiary events including AMI, pulmonary oedema and primary cardiovascular death, whereas RCRI was not associated with primary cardiovascular death.
CRP Binding (associated) of NT-proBNP associated with heart rate under development and death
9) Confidence 0.01 Published 2010 Journal Heart Section Body Doc Link PMC2791233 Disease Relevance 0.47 Pain Relevance 0
Higher CRP and NT-proBNP values were also associated with 2.5-fold to 5.4-fold increased risk of secondary endpoints including AMI, pulmonary oedema, and primary cardiovascular death (p<0.05), whereas higher RCRI was not associated with AMI or primary cardiovascular death (table 4).
CRP Binding (associated) of NT-proBNP associated with heart rate under development and death
10) Confidence 0.01 Published 2010 Journal Heart Section Body Doc Link PMC2791233 Disease Relevance 0.46 Pain Relevance 0
By subgroup analysis, CRP and NT-proBNP were also significantly associated with all secondary endpoints, whereas RCRI was not associated with AMI or primary cardiovascular death.
CRP Binding (associated) of NT-proBNP associated with death
11) Confidence 0.01 Published 2010 Journal Heart Section Body Doc Link PMC2791233 Disease Relevance 0.70 Pain Relevance 0
Not only increasing score of a clinical predictor, RCRI, but also increasing quartile of biomarker levels, NT-proBNP and CRP, was associated with a greater risk of PMCE (p<0.001) (fig 2).
CRP Binding (associated) of NT-proBNP
12) Confidence 0.01 Published 2010 Journal Heart Section Body Doc Link PMC2791233 Disease Relevance 0.97 Pain Relevance 0

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