INT240145

Context Info Confidence 0.18 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0.12

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

Anatomy Link Frequency osteoclasts 2 MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 39 63.04 cytokine 4 54.32 Inflammation 3 53.36 cINOD 4 5.00 Paracetamol 1 5.00 Inflammatory mediators 1 5.00 Analgesic 1 5.00

Disease Link Frequency Relevance Heat Hypercalcemia 11 95.24 Osteoarthritis 40 63.04 INFLAMMATION 5 53.36 Osteoporosis 6 50.00 Disease 7 5.00 Apoptosis 5 5.00 Stress 2 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The role of MMP-13 in bone biology is of major importance as, on the one hand, MMP-13 secretion from the osteoblasts could be responsible for increasing type I collagen degradation and, on the other hand, in osteoclasts it could contribute to an increased bone resorption process.

Positive_regulation (responsible) of Localization (secretion) of MMP-13 in osteoclasts associated with hypercalcemia

1) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.27 Pain Relevance 0.12

General Comments

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