INT240174

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SK-N-FI 3
SK-N-SH 1
Nlf1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 252 99.76 Very High Very High Very High
Cancer 272 99.48 Very High Very High Very High
Apoptosis 16 29.84 Quite Low
Disease 16 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Solid Tumor 4 5.00 Very Low Very Low Very Low
Dislocations 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHD5 protein expression in NLF and IMR5 parental and transfected lines was detected by immunoblotting with rabbit polyclonal anti-CHD5 antiserum (1?
Positive_regulation (transfected) of Gene_expression (transfected) of NLF
1) Confidence 0.06 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.13 Pain Relevance 0
Neuroblastoma cell lines NLF, IMR5, SK-N-SH, and SK-N-FI were stably transfected with a CHD5 sense or antisense (AS) DNA (GenBank accession number AF425231) that had been cloned into the expression vector pcDNA3.1 (Invitrogen, Carlsbad, CA).
Positive_regulation (transfected) of Gene_expression (transfected) of NLF in SK-N-FI associated with neuroblastoma
2) Confidence 0.05 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.19 Pain Relevance 0
Clonogenicity and tumor growth were abrogated in NLF and IMR5 cells overexpressing CHD5 compared with antisense CHD5 (clonogenicity: mean no. of colonies per plate, NLF-CHD5, 43 colonies, 95% confidence interval [CI] = 35 to 51 colonies, vs NLF-CHD5-AS, 74 colonies, 95% CI = 62 to 86 colonies, P < .001; IMR5-CHD5, 11 colonies, 95% CI = 2 to 20 colonies, vs IMR5-CHD5-AS, 39 colonies, 95% CI = 17 to 60 colonies, P = .01; tumor growth, n = 10 mice per group: mean tumor size at 5 weeks, NLF-CHD5, 0.36 cm3, 95% CI = 0.17 to 0.44 cm3, vs NLF-CHD5-AS, 1.65 cm3, 95% CI = 0.83 to 2.46 cm3, P = .002; IMR5-CHD5, 0.28 cm3, 95% CI = 0.18 to 0.38 cm3, vs IMR5-CHD5-AS, 1.15 cm3, 95% CI = 0.43 to 1.87 cm3; P = .01).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NLF associated with cancer
3) Confidence 0.05 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Abstract Doc Link PMC2483574 Disease Relevance 0.74 Pain Relevance 0
Neuroblastoma cell lines NLF, IMR5, SK-N-SH, and SK-N-FI were stably transfected with a CHD5 sense or antisense (AS) DNA (GenBank accession number AF425231) that had been cloned into the expression vector pcDNA3.1 (Invitrogen, Carlsbad, CA).
Positive_regulation (transfected) of in SK-N-SH Gene_expression (transfected) of NLF in SK-N-FI associated with neuroblastoma
4) Confidence 0.02 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.19 Pain Relevance 0

General Comments

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