INT240192

Context Info Confidence 0.08 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0.52

cytosol (RBX1) extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF) nucleus (RBX1) ligase activity (RBX1) cytoplasm (RBX1)

Anatomy Link Frequency SH-SY5Y 1 RBX1 (Homo sapiens) BDNF (Homo sapiens)

Pain Link Frequency Relevance Heat Desipramine 12 99.80 fluoxetine 11 92.80 Serotonin 2 86.60 antidepressant 29 74.32 depression 3 65.68 Hippocampus 1 61.84 sSRI 1 5.00 tricyclic antidepressant 1 5.00

Disease Link Frequency Relevance Heat Stress 3 67.20 Depression 3 65.68 Neuroblastoma 6 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present results suggest that early reduction of total BDNF mRNA in SH-SY5Y cells was mainly accounted for by a reduction of BDNF IV by RBX and DMI administration, and of BDNF VIa/b by RBX.

RBX Negative_regulation (reduction) of BDNF IV in SH-SY5Y associated with desipramine

1) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.13 Pain Relevance 0.52

General Comments

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