INT24020

Context Info Confidence 0.44 First Reported 1987 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 6.14 Pain Relevance 1.08

pigmentation (HPS1) cytoplasmic membrane-bounded vesicle (HPS1) lysosome (HPS1) cytoplasm (HPS1)

Anatomy Link Frequency blood 1 HPS1 (Homo sapiens)

Pain Link Frequency Relevance Heat reflex sympathetic dystrophy 3 100.00 imagery 2 100.00 Inflammation 1 99.72 Pain 3 98.76 Perioperative pain 2 95.24 Opioid 2 80.48 Neurotransmitter 1 74.08 Hippocampus 3 64.16 tetrodotoxin 1 61.20 noradrenaline 1 46.72

Disease Link Frequency Relevance Heat Hantavirus Infection 81 100.00 Complex Regional Pain Syndromes 8 100.00 Dystonia 6 99.76 INFLAMMATION 1 99.72 Infection 26 99.68 Pain 2 98.76 Polyps 35 97.60 Syndrome 42 97.48 Hyperplasia 15 97.32 Disease 4 97.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There has been an increase in the use of Human Patient Simulator (HPS) for teaching advanced courses in pharmacology to medical students, residents, and nurses.

Positive_regulation (increase) of HPS associated with hantavirus infection

1) Confidence 0.44 Published 2010 Journal J Opioid Manag Section Abstract Doc Link 20481177 Disease Relevance 0.38 Pain Relevance 0.43

The HPs are likely to be caused by an increase in potassium conductance; their reversal potential was 15-20 mV negative to rest, the reversal potential shifted in the depolarizing direction when the slice was bathed in high potassium medium, and it was the same with KCl or potassium acetate recording electrodes.

Spec (likely) Positive_regulation (caused) of HPs

2) Confidence 0.40 Published 1987 Journal Brain Res. Section Abstract Doc Link 2441803 Disease Relevance 0 Pain Relevance 0.13

While HPS is caused by different hantaviruses in the two regions, the pattern of persistent pulmonary function abnormalities, expiratory flow reduction, and increased residual volume was similar in both groups, likely due to the common pathogenetic features of HPS seen throughout the Americas.

Positive_regulation (caused) of HPS associated with congenital anomalies and hantavirus infection

3) Confidence 0.40 Published 2010 Journal Lung Section Body Doc Link PMC2939327 Disease Relevance 1.09 Pain Relevance 0

HPS is caused by New World hantaviruses that have been identified since the syndrome was first recognized in the southwestern United States in 1993 (2).

Positive_regulation (caused) of HPS associated with syndrome and hantavirus infection

4) Confidence 0.26 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2730342 Disease Relevance 1.38 Pain Relevance 0

Cerebral activation during motor imagery in complex regional pain syndrome type 1 with dystonia.

Positive_regulation (activation) of complex regional pain syndrome type 1 associated with complex regional pain syndromes, reflex sympathetic dystrophy, dystonia and imagery

5) Confidence 0.12 Published 2008 Journal Pain Section Title Doc Link 17561345 Disease Relevance 1.03 Pain Relevance 0.29

BACKGROUND: In complex regional pain syndrome type 1 (CRPS1) vascular changes occur from the initial, inflammatory event onto the trophic signs during chronicity of the disease, resulting in blood flow disturbances and marked temperature changes.

Positive_regulation (occur) of complex regional pain syndrome type 1 in blood associated with complex regional pain syndromes, inflammation, reflex sympathetic dystrophy and disease

6) Confidence 0.07 Published 2008 Journal Clin J Pain Section Abstract Doc Link 18180642 Disease Relevance 0.37 Pain Relevance 0.22

The precise molecular mechanism that underlies HPS has not currently been determined.

Positive_regulation (underlies) of HPS associated with hantavirus infection

7) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.89 Pain Relevance 0

General Comments

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