INT240201

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 1.09
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
dendrites 2
brain 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 116 99.84 Very High Very High Very High
Hippocampus 46 97.20 Very High Very High Very High
tolerance 6 95.64 Very High Very High Very High
medulla 12 94.40 High High
cerebral cortex 18 94.04 High High
Pain 6 91.48 High High
depression 12 91.04 High High
Desipramine 48 89.20 High High
fluoxetine 44 80.60 Quite High
Serotonin 8 74.40 Quite High
Disease Link Frequency Relevance Heat
Stress 12 92.56 High High
Pain 6 91.48 High High
Depression 12 91.04 High High
Nervous System Malformation 6 87.16 High High
Neuroblastoma 30 86.80 High High
Cognitive Disorder 6 65.68 Quite High
Neurodegenerative Disease 6 57.68 Quite High
Huntington's Chorea 6 54.08 Quite High
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, previous studies in rodents have shown a differential regulation of distinct BDNF transcripts by antidepressant treatments [6,9,11].
Regulation (regulation) of Transcription (transcripts) of BDNF associated with antidepressant
1) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.18 Pain Relevance 0.45
Therefore, aim of the present study was to investigate whether antidepressant treatments of different time lengths induce changes in the expression of BDNF gene also in cultured human cells and to assess whether these modifications could be explained by differential regulation of BDNF transcripts.
Regulation (regulation) of Transcription (transcripts) of BDNF associated with antidepressant
2) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.23 Pain Relevance 0.16
Other possible regulatory functions of antiBDNF would be direct inhibition of BDNF transcription or translation and/or regulation of BDNF pre-mRNA splicing.
Regulation (regulation) of Transcription (transcription) of BDNF
3) Confidence 0.40 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
Other possible regulatory functions of antiBDNF would be direct inhibition of BDNF transcription or translation and/or regulation of BDNF pre-mRNA splicing.
Regulation (regulation) of Transcription (transcription) of BDNF
4) Confidence 0.40 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
The transcription start sites for the BDNF and antiBDNF transcripts were detected with 5?
Regulation (sites) of Transcription (transcripts) of BDNF
5) Confidence 0.40 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.04
Fewer data are available about BDNF mRNA expression.
Regulation (available) of Transcription (expression) of BDNF
6) Confidence 0.40 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.09
Second, to identify novel BDNF transcripts and to determine the transcription start sites for the human BDNF transcripts, 5?
Spec (determine) Regulation (sites) of Transcription (transcripts) of BDNF
7) Confidence 0.35 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.14
Recent rodent studies reported that antidepressant treatments affect the expression of brain-derived neurotrophic factor (BDNF) mRNA in a way that is dependent on treatment duration, by selective modulation of different BDNF transcripts.
Regulation (affect) of Transcription (expression) of BDNF in brain associated with antidepressant
8) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2483719 Disease Relevance 0.15 Pain Relevance 0.27
The underlying molecular mechanisms are at present unknown; however, recent evidence from several groups suggest that different signaling mechanisms may be responsible for the regulation of BDNF transcription [2].
Regulation (regulation) of Transcription (transcription) of BDNF
9) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.16 Pain Relevance 0.24
Data accumulated in recent years suggest that neuronal activity regulates transcription of BDNF, transport of BDNF mRNA and protein into dendrites, and secretion of BDNF protein, which are important for the formation of appropriate synaptic connections and for learning and memory during development and in adults [6].
Regulation (regulates) of Transcription (transcription) of BDNF in dendrites
10) Confidence 0.21 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.36 Pain Relevance 0.18

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