INT240204

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 29 99.98 Very High Very High Very High
depression 4 91.76 High High
Desipramine 12 5.00 Very Low Very Low Very Low
fluoxetine 11 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
sSRI 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
tricyclic antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 59 98.10 Very High Very High Very High
Depression 4 91.76 High High
Affective Disorder 2 63.32 Quite High
Neuroblastoma 7 50.00 Quite Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, different and sometimes conflicting findings have been reported [2], showing that antidepressants change total BDNF expression level depending on length of the treatment and time interval following administration.
Regulation (depending) of Regulation (change) of BDNF associated with antidepressant
1) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.33 Pain Relevance 0.23
Acute stress induces also a significant increase in proBDNF levels and reduction in mature BDNF suggesting altered regulation of proBDNF proteolytic processing.
Regulation (altered) of Regulation (regulation) of proBDNF associated with stress
2) Confidence 0.21 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2829032 Disease Relevance 0.83 Pain Relevance 0

General Comments

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