INT240205

Context Info Confidence 0.26 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.44 Pain Relevance 0.28

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1) cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)

MAP2K1 (Homo sapiens)

Pain Link Frequency Relevance Heat antidepressant 29 98.20 Arthritis 64 84.36 rheumatoid arthritis 65 78.12 Hippocampus 2 61.20 depression 3 59.24 Inflammation 43 50.00 cytokine 15 48.88 Desipramine 12 42.00 fluoxetine 11 33.40 chemokine 2 30.48

Disease Link Frequency Relevance Heat Arthritis 62 84.36 Rheumatoid Arthritis 65 78.12 Depression 3 59.24 Stress 4 58.32 Neutropenia 2 56.80 Diarrhoea 1 56.12 Neuroblastoma 6 50.00 Osteoporosis 1 34.24 Synovitis 1 22.64 INFLAMMATION 17 6.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, MKK activity is also regulated by further upstream MKKK and MKKKK activity that are either tyrosine or serine-binding proteins which may also require low molecular weight GTP-binding proteins for MKKK activation.

Regulation (regulated) of MKK

1) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.33 Pain Relevance 0.11

These results suggest that LPA and S1P promote growth of hES-NEP cells through a mechanism dependent on Ptx-sensitive Gi/o G-proteins, EGF receptor, MEK, and ERK, but independent of the Rho-associated kinase p160ROCK.

Regulation (dependent) of MEK

2) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0

In this regard, we have recently reported that chronic administration of different antidepressants in rats exerts distinct actions on CREB activation that seem to depend on a differential modulation of CaM kinase IV and MAPK-Erk1/2 cascades [31].

Regulation (modulation) of MAPK-Erk1 associated with antidepressant

3) Confidence 0.00 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.12 Pain Relevance 0.17

General Comments

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