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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1)
cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)
MAP2K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 29 98.20 Very High Very High Very High
Arthritis 64 84.36 Quite High
rheumatoid arthritis 65 78.12 Quite High
Hippocampus 2 61.20 Quite High
depression 3 59.24 Quite High
Inflammation 43 50.00 Quite Low
cytokine 15 48.88 Quite Low
Desipramine 12 42.00 Quite Low
fluoxetine 11 33.40 Quite Low
chemokine 2 30.48 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 62 84.36 Quite High
Rheumatoid Arthritis 65 78.12 Quite High
Depression 3 59.24 Quite High
Stress 4 58.32 Quite High
Neutropenia 2 56.80 Quite High
Diarrhoea 1 56.12 Quite High
Neuroblastoma 6 50.00 Quite Low
Osteoporosis 1 34.24 Quite Low
Synovitis 1 22.64 Low Low
INFLAMMATION 17 6.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, MKK activity is also regulated by further upstream MKKK and MKKKK activity that are either tyrosine or serine-binding proteins which may also require low molecular weight GTP-binding proteins for MKKK activation.
Regulation (regulated) of MKK
1) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.33 Pain Relevance 0.11
These results suggest that LPA and S1P promote growth of hES-NEP cells through a mechanism dependent on Ptx-sensitive Gi/o G-proteins, EGF receptor, MEK, and ERK, but independent of the Rho-associated kinase p160ROCK.
Regulation (dependent) of MEK
2) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
In this regard, we have recently reported that chronic administration of different antidepressants in rats exerts distinct actions on CREB activation that seem to depend on a differential modulation of CaM kinase IV and MAPK-Erk1/2 cascades [31].
Regulation (modulation) of MAPK-Erk1 associated with antidepressant
3) Confidence 0.00 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.12 Pain Relevance 0.17

General Comments

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