INT240278

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 9.44
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFALS) extracellular space (IGFALS) extracellular region (IGFALS)
cell adhesion (IGFALS) nucleolus (IGFALS) nucleus (IGFALS)
Anatomy Link Frequency
muscles 1
lateral 1
IGFALS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 32 98.64 Very High Very High Very High
imagery 31 75.96 Quite High
Neurobehavioral 13 67.68 Quite High
Central nervous system 16 53.52 Quite High
withdrawal 3 50.16 Quite High
Somatostatin 2 14.92 Low Low
Inflammation 26 5.00 Very Low Very Low Very Low
Neuritis 15 5.00 Very Low Very Low Very Low
Peripheral nervous system 12 5.00 Very Low Very Low Very Low
Dopamine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 534 100.00 Very High Very High Very High
Disease 296 100.00 Very High Very High Very High
Neurodegenerative Disease 57 100.00 Very High Very High Very High
Charcot Marie Tooth Disease 7 100.00 Very High Very High Very High
Atrophy 7 98.96 Very High Very High Very High
Thyroid Disease 31 97.72 Very High Very High Very High
Death 60 96.36 Very High Very High Very High
Hypothyroidism 2 95.68 Very High Very High Very High
Thyroiditis 1 93.64 High High
Toxicity 36 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The subcutaneously administration of rhIGF1 does not correct the low circulating levels of IGFBP-3 and ALS and therefore the clearance of rhIGF1 is accelerated and the tissue distribution affected.33 Moreover, it has been described that prolonged administration of rhIGF1 leads to generation of IGFBP-3 and ALS and other binding proteins, requiring sometimes a reduction of rhIGF1 dosage to prevent adverse effects.2 The possible direct effect of GH on skeletal growth should also be considered.
Localization (generation) of ALS
1) Confidence 0.53 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.07 Pain Relevance 0
Although the definite etiology of ALS remains unclear, occupational or environmental exposure has been considered as one of the potential causes of ALS.
Localization (etiology) of ALS associated with motor neuron diseases
2) Confidence 0.49 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC3023358 Disease Relevance 0.93 Pain Relevance 0.24
Amyotrophic lateral sclerosis (ALS), Motor neurone disease (MND), Charcot's disease, Lou Gehrig's disease

Included diseases

Localization (disease) of ALS in lateral associated with charcot marie tooth disease, disease and motor neuron diseases
3) Confidence 0.42 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 2.17 Pain Relevance 0
There have been some interesting associations reported with ALS/MND, calcium and vitamin D metabolism.
Localization (reported) of ALS associated with motor neuron diseases
4) Confidence 0.38 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 2.01 Pain Relevance 0
Next, we collected longitudinal CSF samples from ALS patients and assessed the effect of time on cystatin C levels using a statistical model for repeated measures.
Localization (samples) of ALS associated with motor neuron diseases
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.67 Pain Relevance 0
Kaplan–Meier curves of survival for different fALS-causing SOD1 mutations, non-SOD1-related fALS, and sALS were generated.
Localization (generated) of fALS
6) Confidence 0.27 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.23 Pain Relevance 0.03
We expanded upon these studies with a larger set of fALS-causing SOD1 mutations as well as larger patient cohorts.
Localization (set) of fALS
7) Confidence 0.27 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.72 Pain Relevance 0
This study of Jimi and colleagues showed that changes in the levels of AQP4 mRNA in muscles with ALS and other neurogenic atrophies were essentially the same, although there was a greater decrease of AQP4 in ALS than in other neurogenic atrophies.
Localization (decrease) of ALS in muscles associated with atrophy and motor neuron diseases
8) Confidence 0.13 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.81 Pain Relevance 0
Kaplan–Meier curves of survival for different fALS-causing SOD1 mutations, non-SOD1-related fALS, and sALS were generated.
Localization (generated) of fALS
9) Confidence 0.12 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.23 Pain Relevance 0.03
ALS is another neurodegenerative disease in which iron has been strongly implicated (and thus the same kinds of mechanism as described previously) (Bush 2000; Carri et al. 2003; Cozzolino et al. 2008; Goodall et al. 2008; Jeong et al. 2009; Kasarskis et al. 1995; Mattson 2004; Migliore et al. 2005; Molfino et al. 2009; Qureshi et al. 2008; Reynolds et al. 2007; Sadrzadeh and Saffari 2004; Sayre et al. 2000a; Scott and Orvig 2009; Spasojevi?
Localization (disease) of ALS associated with neurodegenerative disease
10) Confidence 0.04 Published 2010 Journal Arch Toxicol Section Body Doc Link PMC2988997 Disease Relevance 0.60 Pain Relevance 0
Moreover, Schmid et al. [29] showed that, during L-T4 replacement, IGF-I and acid-labile subunit secretion increased in the patients with both primary and central hypothyroidism, while IGFBP-3 - only in those with primary hypothyroidism.
Localization (secretion) of acid-labile subunit associated with hypothyroidism and thyroid disease
11) Confidence 0.01 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 1.01 Pain Relevance 0

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