INT240279

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.45
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 9 93.08 High High
palliative 2 71.36 Quite High
ischemia 1 70.88 Quite High
Inflammation 42 63.32 Quite High
anesthesia 1 29.80 Quite Low
Bile 39 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 29 99.48 Very High Very High Very High
Lung Injury 4 96.24 Very High Very High Very High
Cancer 65 91.84 High High
Heart Rate Under Development 52 91.24 High High
Urological Neuroanatomy 16 90.40 High High
Bacterial Respiratory Disease 2 87.76 High High
Mycoplasma Infection 1 80.64 Quite High
Motor Neuron Diseases 35 76.48 Quite High
Nicotine Addiction 1 72.80 Quite High
Cv Unclassified Under Development 1 70.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The severity of fALS thus is related to mutation-induced increases in SOD1 aggregation propensity.
Negative_regulation (aggregation) of Positive_regulation (increases) of SOD1
1) Confidence 0.43 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.15 Pain Relevance 0.07
The mechanisms of the protective effects of taurine may be related to the decrease of MDA level and the increase of SOD and GPx activity.
Negative_regulation (decrease) of Positive_regulation (increase) of SOD
2) Confidence 0.06 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2583976 Disease Relevance 0.78 Pain Relevance 0.07
For the in vivo SOD induction study
Negative_regulation (vivo) of Positive_regulation (induction) of SOD
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.47 Pain Relevance 0
However, Dincer, et al.46 reported decreased glutathione peroxidase (GSH-Px) and increased SOD activity in gastric cancer patients when compared to healthy subjects.
Negative_regulation (decreased) of Positive_regulation (increased) of SOD associated with stomach cancer
4) Confidence 0.03 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768243 Disease Relevance 0.82 Pain Relevance 0
SOD and CAT may not be direct transcriptional targets of SXR and the mechanism of SXR-mediated downregulation of SOD and CAT activities remains to be determined.
Negative_regulation (downregulation) of Positive_regulation (activities) of SOD
5) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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