INT240281

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 10.44
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFALS) extracellular space (IGFALS) extracellular region (IGFALS)
cell adhesion (IGFALS) nucleolus (IGFALS) nucleus (IGFALS)
Anatomy Link Frequency
CSF 1
motor neuron 1
IGFALS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 43 92.56 High High
excitatory amino acid 2 89.12 High High
Glutamate 8 83.08 Quite High
Glutamate receptor 4 77.20 Quite High
nMDA receptor 2 74.24 Quite High
fluoxetine 1 64.80 Quite High
cytokine 4 63.12 Quite High
antidepressant 1 62.88 Quite High
Inflammation 19 62.72 Quite High
withdrawal 3 50.16 Quite High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 936 100.00 Very High Very High Very High
Paraproteinemias 16 99.76 Very High Very High Very High
Disease 342 99.44 Very High Very High Very High
Toxicity 24 99.04 Very High Very High Very High
Neurodegenerative Disease 59 97.56 Very High Very High Very High
Death 45 96.76 Very High Very High Very High
Hypercalcemia 76 95.96 Very High Very High Very High
Spinal Muscular Atrophy 28 95.60 Very High Very High Very High
Stress 8 91.64 High High
Apoptosis 13 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over 250 cases of defects of GH receptors (GHR) have been described to date and over 60 of them are due to GHR gene mutations affecting the capacity of the receptor of binding, dimerizing, migrating, or initiating postreceptor cascade.6 Also mutations in STAT-5b,7 IGF-1,8 that leads to a bioinactive IGF-1, and acid labile subunit (ALS)9 genes, have been reported.


Positive_regulation (leads) of ALS
1) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.76 Pain Relevance 0
In humans, three mutations in the VEGF gene were found to be associated with increased risk of developing sporadic ALS [99], although a recent meta-analysis by the same authors failed to show an association between VEGF haplotypes and increase the risk of ALS in humans [145].
Neg (failed) Positive_regulation (increase) of ALS associated with motor neuron diseases
2) Confidence 0.28 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 1.83 Pain Relevance 0.12
As mutations in the anti-oxidant enzyme superoxide dismutase 1 (SOD1) gene can cause familial ALS, there is significant interest in this mechanism underlying neurodegenerative process in ALS.
Positive_regulation (cause) of ALS associated with neurodegenerative disease and motor neuron diseases
3) Confidence 0.26 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 1.42 Pain Relevance 0.23
This corresponded with the El Escorial criteria classification of 'clinically probable laboratory supported ALS'.
Positive_regulation (supported) of ALS associated with motor neuron diseases
4) Confidence 0.26 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 0.61 Pain Relevance 0
One had ALS and IgG?
Positive_regulation (had) of ALS associated with motor neuron diseases
5) Confidence 0.26 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.45 Pain Relevance 0
Post-hoc analyses revealed that total and percent cystatin C were significantly increased in both ALS patients and disease controls relative to healthy controls.
Positive_regulation (increased) of ALS associated with disease and motor neuron diseases
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.54 Pain Relevance 0
Cystatin C levels in ALS patients were significantly elevated in plasma and reduced in CSF compared to healthy controls, but did not differ significantly from neurologic disease controls.
Positive_regulation (elevated) of ALS in CSF associated with disease and motor neuron diseases
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3000338 Disease Relevance 1.24 Pain Relevance 0
Fifteen years after the discovery that SOD1 mutations can cause ALS [1], the mechanisms of toxicity are still not well understood.
Positive_regulation (cause) of ALS associated with toxicity and motor neuron diseases
8) Confidence 0.18 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.68 Pain Relevance 0
-sheets, correlate with decreased fALS patient survival, while decreases of the magnitude of net charge correlate with increased fALS patient survival, in contradiction with previous reports [15,68].
Positive_regulation (increased) of fALS
9) Confidence 0.18 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0 Pain Relevance 0
The platform was conceptualized for a broad set of conditions and was first implemented for amyotrophic lateral sclerosis (ALS), also called motor neuron disease or Lou GehrigÂ’s disease.
Positive_regulation (implemented) of ALS in motor neuron associated with disease and motor neuron diseases
10) Confidence 0.17 Published 2008 Journal Journal of Medical Internet Research Section Body Doc Link PMC2553248 Disease Relevance 0.86 Pain Relevance 0.10
Kaplan–Meier curves of survival for different fALS-causing SOD1 mutations, non-SOD1-related fALS, and sALS were generated.
Positive_regulation (generated) of fALS
11) Confidence 0.07 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.23 Pain Relevance 0.03
This concept was already approached by Kaiser and colleagues [44], who observed a progressive loss of Kir4.1 and a slight increase in AQP4 protein in the mouse ALS model.
Positive_regulation (increase) of ALS associated with motor neuron diseases
12) Confidence 0.07 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.81 Pain Relevance 0.09

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