INT240359

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 11.67
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnc) extracellular space (Tnc) extracellular region (Tnc)
cell adhesion (Tnc) proteinaceous extracellular matrix (Tnc)
Anatomy Link Frequency
skin 3
leukocyte 1
Tnc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 99.44 Very High Very High Very High
Lamotrigine 42 99.08 Very High Very High Very High
cINOD 35 98.78 Very High Very High Very High
carbamazepine 84 97.32 Very High Very High Very High
cerebral cortex 12 50.64 Quite High
antiepileptic Drug 21 50.32 Quite High
corticosteroid 42 46.08 Quite Low
dexamethasone 14 39.40 Quite Low
cytokine 21 5.00 Very Low Very Low Very Low
withdrawal 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Staphylococcus Infection 896 100.00 Very High Very High Very High
Bullous Skin Disease 742 100.00 Very High Very High Very High
Syndrome 35 100.00 Very High Very High Very High
Genetic Predisposition To Disease 14 100.00 Very High Very High Very High
Skin Infection 7 100.00 Very High Very High Very High
INFLAMMATION 14 99.44 Very High Very High Very High
Adverse Drug Reaction 28 97.20 Very High Very High Very High
Acute Generalized Exanthematous Pustulosis 49 94.40 High High
Hydrocephalus 39 91.72 High High
Embolism 7 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did not assay other proteoglycans of the lectican family (e.g. aggrecan, versican, or brevican), hyaluronan, or tenascin, which all interact in the extracellular compartment [50].
tenascin Binding (interact) of
1) Confidence 0.35 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2488327 Disease Relevance 0.50 Pain Relevance 0.03
Genetic susceptibility to SJS and TEN is likely as exemplified by the strong association observed in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and SJS induced by carbamazepine.
TEN Binding (susceptibility) of in leukocyte associated with staphylococcus infection, genetic predisposition to disease, bullous skin disease and carbamazepine
2) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC3018455 Disease Relevance 2.36 Pain Relevance 0.19
Subsequently, a strong association between SJS/TEN and HLA-B*5801 was found in Japanese patients [34], Thai patients [32], and also, to a lesser extent (55% of cases), in patients of European origin [36].


TEN Binding (association) of associated with staphylococcus infection and bullous skin disease
3) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.01 Pain Relevance 0.43
A second strong association between HLA genotype and SJS/TEN has been reported for allopurinol.
TEN Binding (association) of associated with staphylococcus infection and bullous skin disease
4) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.56 Pain Relevance 0.53
The Nikolsky sign is positive if mechanical pressure induces epidermal detachment, but is not specific for TEN or SJS, as it can also be positive in, for example, autoimmune bullous skin diseases.
TEN Binding (specific) of in skin associated with staphylococcus infection and bullous skin disease
5) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 0.73 Pain Relevance 0
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


TEN Binding (syndrome) of in skin associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
6) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.92 Pain Relevance 0.15
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


TEN Binding (syndrome) of in skin associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
7) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.94 Pain Relevance 0.15
Taken together, although each study has its potential biases and the 12 studies are not directly comparable, 9 of the 12 studies suggest that there may be a benefit of high-dose IVIG on the mortality associated with TEN [44,69,72,74-82].
TEN Binding (associated) of associated with staphylococcus infection
8) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 0.64 Pain Relevance 0

General Comments

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