INT24042

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 98
Total Number 103
Disease Relevance 74.99
Pain Relevance 6.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC5AC) cell adhesion (MUC5AC)
Anatomy Link Frequency
epithelium 8
pancreas 5
tear 4
blood 3
eye 3
MUC5AC (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 97 99.92 Very High Very High Very High
metalloproteinase 341 98.92 Very High Very High Very High
gABA 1121 98.84 Very High Very High Very High
headache 47 98.24 Very High Very High Very High
Inflammation 414 96.76 Very High Very High Very High
GABAergic 874 96.48 Very High Very High Very High
Bile 64 92.44 High High
chemokine 73 91.72 High High
agonist 135 91.52 High High
cytokine 225 91.12 High High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 1105 100.00 Very High Very High Very High
Sprains And Strains 301 100.00 Very High Very High Very High
Eye Disease 56 100.00 Very High Very High Very High
Metastasis 285 99.96 Very High Very High Very High
Meningitis 174 99.96 Very High Very High Very High
Hyperplasia 110 99.96 Very High Very High Very High
Pancreatitis 136 99.92 Very High Very High Very High
Hemolytic Anemia 30 99.92 Very High Very High Very High
Adenocarcinoma 247 99.88 Very High Very High Very High
Cancer 1096 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin.
Gene_expression (expression) of MUC5AC in Anal canal associated with adenocarcinoma
1) Confidence 0.77 Published 2007 Journal Med Mol Morphol Section Title Doc Link 17384991 Disease Relevance 0.73 Pain Relevance 0.09
Atypical mucous duct hyperplasia near cancer cells consistently expressed MUC1 apomucin and occasionally expressed MUC3 and MUC5/6.
Gene_expression (expressed) of MUC5 in duct associated with cancer and hyperplasia
2) Confidence 0.75 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.86 Pain Relevance 0.06
IPMNs with a high expression of MUC2 and MUC5AC have a lower invasion and metastasising potential in comparison to DACs and therefore a better clinical outcome [36-39].
Gene_expression (expression) of MUC5AC
3) Confidence 0.70 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.81 Pain Relevance 0
There are contrary data about the detection of MUC5AC and MUC5B in normal pancreas [19,22,23].
Gene_expression (detection) of MUC5AC in pancreas
4) Confidence 0.70 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.17 Pain Relevance 0
In a recent study, overexpression of MUC6 and the de novo expression of gastric secretory mucin MUC5AC in all stages of PanINs and in invasive DACs was described on RNA and protein level [22].
Gene_expression (expression) of MUC5AC
5) Confidence 0.70 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.86 Pain Relevance 0
The ocular surface epithelium expresses at least four major mucin genes: MUCIN 1 (MUC1), MUCIN 4 (MUC4), MUCIN 5AC (MUC5AC), and MUCIN 16 (MUC16).
Gene_expression (expresses) of MUC5AC in surface epithelium
6) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.10 Pain Relevance 0
Deletion of an expected A, B, H, or Leb antigen occurred in approximately 25% of cases, particularly in more poorly differentiated cancers.
Gene_expression (Deletion) of Leb associated with cancer
7) Confidence 0.65 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 2442445 Disease Relevance 1.13 Pain Relevance 0.27
A recent study has shown that non-invasive MCNs can be distinguished from IPMNs and DACs by the mucin profile that is characterized by expression of MUC5AC, whereas MUC2 expression is restricted to globlet cells [40].
Gene_expression (expression) of MUC5AC associated with cancer
8) Confidence 0.61 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.31 Pain Relevance 0.10
Studies revealed that IPMNs in general express MUC2, MUC5AC and mostly MUC4 whereas MUC1 is absent [36-39].
Neg (absent) Gene_expression (express) of MUC5AC
9) Confidence 0.61 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.88 Pain Relevance 0
MUC5AC is a gel-forming secretory mucin expressed by conjunctival goblet cells.
Gene_expression (expressed) of MUC5AC in goblet cells
10) Confidence 0.60 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.64 Pain Relevance 0
The MUC5AC protein levels in the tear fluid were determined by Enzyme-Linked ImmunoSorbent Assay (ELISA).
Gene_expression (levels) of MUC5AC in tear
11) Confidence 0.60 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994764 Disease Relevance 0.42 Pain Relevance 0
We also show, for the fist time, that induction of Gob-5 and Muc5-ac expression was blocked in the presence of a constitutively active PPAR-?
Gene_expression (expression) of Muc5-ac
12) Confidence 0.58 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.35 Pain Relevance 0.36
In pancreatic mucinous cystadenoma (n = 8), MUC1, MUC2, MUC3, and MUC5/6 apomucins were expressed in 7/8 (88 percent), 0/8 (0 percent), (25 percent), and 3/8 (38 percent) cases, respectively.
Gene_expression (expressed) of MUC5 associated with mucinous cystadenoma
13) Confidence 0.58 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.75 Pain Relevance 0.08
2, the ability of CRA to induce expression of Gob-5 and Muc5-ac was significantly suppressed (P < 0.05) compared to mice given control adenovirus (Fig. 4C).
Gene_expression (expression) of Muc5-ac
14) Confidence 0.58 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.47 Pain Relevance 0.28
The epithelial expression of apomucins MUC1, MUC2, MUC3, and MUC5/6 was examined in normal pancreas and in pancreatic lesions, using immunohistochemical methods.
Gene_expression (expression) of MUC5 in pancreas
15) Confidence 0.58 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.35 Pain Relevance 0.08
In intraductal papillary-mucinous neoplasm (IPMN) of the pancreas (n = 9), MUC1, MUC2, MUC3, and MUC5/6 apomucins were expressed in 8/9 (89 percent), 0/9 (0 per cent), 4/9 (44 per cent), and 9/9 (100 per cent) case, respectively.
Gene_expression (expressed) of MUC5 in pancreas associated with cancer
16) Confidence 0.58 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.73 Pain Relevance 0.09
As the main mucin component of the tear film, MUC5AC is believed to play an important role in attainment of tear stability and in prevention of drying on the ocular surface [3].
Gene_expression (component) of MUC5AC in tear
17) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.75 Pain Relevance 0.04
In this study, we found the MUC5AC recovered to the pre-operative level at 3 months after surgery.
Gene_expression (recovered) of MUC5AC
18) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.79 Pain Relevance 0.05
Acinar cells expressed A, B, H, and Leb in supranuclear cytoplasm, whereas Lea was found mainly on centroacinar cells.
Gene_expression (expressed) of Leb in Acinar cells
19) Confidence 0.58 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 2442445 Disease Relevance 0.79 Pain Relevance 0.24
Based on this criteria, 3 healthy smokers with high GAD67 and high MUC5AC gene expression and 3 healthy smokers with low GAD67 and low MUC5AC gene expression were assessed for MUC5AC protein expression by immunofluorescence staining.


Gene_expression (expression) of MUC5AC gene associated with nicotine addiction
20) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.27 Pain Relevance 0.04

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