INT240423

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.27
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsa) mitochondrion (Ctsa) nucleus (Ctsa)
lysosome (Ctsa)
Anatomy Link Frequency
leukocytes 1
paw 1
Ctsa (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 149 96.16 Very High Very High Very High
Inflammation 125 75.72 Quite High
cytokine 7 57.04 Quite High
Inflammatory response 4 53.28 Quite High
Arthritis 51 38.52 Quite Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenomatous Polyps 15 99.84 Very High Very High Very High
Polyps 120 99.36 Very High Very High Very High
Pick Disease Of The Brain 3 97.96 Very High Very High Very High
Cancer 119 97.44 Very High Very High Very High
Gauchers Disease 3 96.96 Very High Very High Very High
Disease 114 92.60 High High
Pressure And Volume Under Development 34 92.40 High High
Targeted Disruption 21 90.76 High High
Parkinson's Disease 59 86.12 High High
Cleidocranial Dysplasia 45 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we provide evidence that in addition to cathepsin B, another member of the cysteine family of cathepsin Z is significantly up regulated in adenomatous polyps.
Regulation (regulated) of cathepsin associated with adenomatous polyps
1) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.26 Pain Relevance 0.28
Surprisingly, cathepsin B deficiency predominantly affected the CD11b+Gr1+ MDSC infiltrate, and did not impact the CD11b+F480+ macrophage component of polyp infiltrating leukocytes.
Regulation (affected) of cathepsin in leukocytes associated with polyps
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.05 Pain Relevance 0.13
In contrast to the effects of the p38 MAPK inhibitor, celecoxib treatment had no obvious effect on the cathepsin and MMP signals in any paw region.
Neg (no) Regulation (effect) of cathepsin in paw
3) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911895 Disease Relevance 0.37 Pain Relevance 0.20
Moreover, recent studies have shown that reduced Cathepsin D expression results in ?
Regulation (results) of Cathepsin
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.35 Pain Relevance 0
Here we provide evidence that in addition to cathepsin B, another member of the cysteine family of cathepsin Z is significantly up regulated in adenomatous polyps.
Regulation (regulated) of cathepsin associated with adenomatous polyps
5) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.24 Pain Relevance 0.28

General Comments

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