INT240424

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.94
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsa) mitochondrion (Ctsa) nucleus (Ctsa)
lysosome (Ctsa)
Ctsa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 58 86.48 High High
midbrain 13 81.32 Quite High
medulla 28 59.12 Quite High
imagery 63 50.00 Quite Low
Spinal cord 17 44.76 Quite Low
Glutamate 5 34.28 Quite Low
cerebral cortex 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 88 99.92 Very High Very High Very High
Polyps 80 92.88 High High
Cleidocranial Dysplasia 30 92.08 High High
Disease 136 90.32 High High
Targeted Disruption 124 90.16 High High
INFLAMMATION 64 86.48 High High
Epilepsy 4 83.32 Quite High
Dementia 6 82.16 Quite High
Cognitive Disorder 4 79.96 Quite High
Dysarthria 7 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To reveal the cellular source of cathepsin activity, APC?
cathepsin Binding (activity) of associated with familial adenomatous polyposis
1) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.47 Pain Relevance 0
To quantify specific protease activity, we used DCG-04, a biotinylated derivative of the non-specific cathepsin inhibitor JPM-565 that interacts with the active site of cysteine cathepsins [21], [22].
cathepsin Binding (interacts) of
2) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.36 Pain Relevance 0.04
-syn because of its lower level of cathepsin D which is recently proved to effectively degrade ?
cathepsin D Binding (level) of
3) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.39 Pain Relevance 0.12
The remainder have mutations in the NPC2 gene, which encodes a small soluble lysosomal protein that binds cholesterol with high affinity [16,55,56].
lysosomal protein Binding (binds) of
4) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 1.72 Pain Relevance 0

General Comments

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