INT240455

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ephb1, Prkaca) plasma membrane (Ephb1, Prkaca) nucleoplasm (Prkaca)
endosome (Ephb1) mitochondrion (Prkaca) Golgi apparatus (Prkaca)
Anatomy Link Frequency
neurons 2
Ephb1 (Rattus norvegicus)
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 2 99.98 Very High Very High Very High
Neuronal excitability 1 99.96 Very High Very High Very High
long-term potentiation 4 96.76 Very High Very High Very High
Spinal cord 5 93.08 High High
Pain 69 91.56 High High
amygdala 97 85.16 High High
Arthritis 43 81.76 Quite High
withdrawal 19 79.32 Quite High
central sensitization 7 76.96 Quite High
Antinociceptive 3 65.84 Quite High
Disease Link Frequency Relevance Heat
Pain 69 91.56 High High
Arthritis 63 81.76 Quite High
Hypersensitivity 1 73.60 Quite High
Nociception 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In dorsal horn neurons activation of PKA, PKC, or ERK increased neuronal excitability and inhibited transient potassium (A-type) currents.
ERK Positive_regulation (increased) of Positive_regulation (activation) of PKA in neurons associated with neuronal excitability and dorsal horn neuron
1) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.63 Pain Relevance 1.01

General Comments

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