INT240461

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.66
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 86 96.44 Very High Very High Very High
Pain 138 96.08 Very High Very High Very High
Arthritis 86 95.88 Very High Very High Very High
amygdala 194 95.20 Very High Very High Very High
agonist 1 72.08 Quite High
Antinociceptive 6 62.24 Quite High
aspirin 2 57.20 Quite High
Inflammatory mediators 3 51.40 Quite High
antagonist 20 33.32 Quite Low
alcohol 2 13.16 Low Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 150 99.22 Very High Very High Very High
Pain 138 96.08 Very High Very High Very High
Arthritis 126 95.88 Very High Very High Very High
Injury 5 87.60 High High
Sepsis 20 70.88 Quite High
Hypertrophy 36 64.32 Quite High
Dyspnea 1 54.36 Quite High
Pulmonary Heart Disease 1 53.12 Quite High
INFLAMMATION 19 51.00 Quite High
Hypoxia 9 40.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The additive effect of PKA and ERK inhibitors suggest that PKA and ERK do not simply act in a serial arrangement in which one inhibitor would occlude the effect of the other.
Regulation (effect) of Negative_regulation (inhibitors) of ERK
1) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.22 Pain Relevance 0.19
PKA and ERK inhibitors selectively affect synaptic plasticity but not normal transmission (Figures 2, 3, 4) and can phosphorylate NMDA receptors [41-43].
Neg (not) Regulation (affect) of Negative_regulation (inhibitors) of ERK associated with nmda receptor
2) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.47 Pain Relevance 0.68
Interestingly, ERK inhibition did not affect occludin concentration, in either septic or control monolayers.
Neg (not) Regulation (affect) of Negative_regulation (inhibition) of ERK
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.21 Pain Relevance 0.03
A single injection of ONO-1301MS resulted in sustained activity for 3 weeks, and attenuated PAH, partly through its antiproliferative effect on vascular SMCs via inhibition of ERK phosphorylation [8].
Regulation (effect) of Negative_regulation (inhibition) of ERK associated with pulmonary hypertension
4) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.77 Pain Relevance 0.06

General Comments

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